Steroid sulfation and desulfation are fundamental pathways vital for a functional vertebrate
endocrine system. After biosynthesis, hydrophobic steroids are sulfated to expedite …

Drug discovery and development is a high-risk, expensive endeavor and it commonly takes
about 10− 15 years to obtain marketing approval from project inception. 1 Research efforts …

Many neuroactive substances, including endogenous biomolecules, environmental
compounds, and pharmaceuticals possess primary amine functional groups. Among these …

In pharmaceutical research, understanding the biodistribution, accumulation and
metabolism of drugs in tissue plays a key role during drug discovery and development. In …

Chronic exposure to elevated levels of glucocorticoids has been linked to age-related
cognitive decline and may play a role in Alzheimer's disease. In the brain, 11β …

Highlights•We review the role of renal 11β-hydroxysteroid dehydrogenase enzymes in blood
pressure regulation.•Renal 11βHSD2 is not merely a 'guardian'of the mineralocorticoid …

Abstract 11Beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1) locally amplifies active
glucocorticoids within specific tissues including in brain. In the hippocampus, 11β-HSD1 …

Hydrophilic quaternary ammonium compounds (QACs) include derivatives of carnitine (Car)
or choline, which are known to have essential bioactivities. Here we developed a technique …

The aim of the present work was to study the influence of variable stress on the expression
of 11β-hydroxysteroid dehydrogenase type 1 (11HSD1) and the neuropeptides corticotropin …

High glucocorticoid levels induced by stress enhance the memory of fearful events and may
contribute to the development of anxiety and posttraumatic stress disorder. In contrast …