CAV-2—why a canine virus is a neurobiologist's best friend
F Junyent, EJ Kremer - Current opinion in pharmacology, 2015 - Elsevier
Highlights•CAV-2 vectors preferentially transduce neurons in rodents and
primates.•Retrograde axonal transport leads to widespread biodistribution in the brain …
primates.•Retrograde axonal transport leads to widespread biodistribution in the brain …
DREADD: a chemogenetic GPCR signaling platform
H Zhu, BL Roth - International Journal of …, 2015 - academic.oup.com
Recently, we created a family of engineered G protein-coupled receptors (GPCRs) called
DREADD (designer receptors exclusively activated by designer drugs) which can precisely …
DREADD (designer receptors exclusively activated by designer drugs) which can precisely …
[HTML][HTML] Targeted genetic manipulations of neuronal subtypes using promoter-specific combinatorial AAVs in wild-type animals
HS Gompf, EA Budygin, PM Fuller… - Frontiers in behavioral …, 2015 - frontiersin.org
Techniques to genetically manipulate the activity of defined neuronal subpopulations have
been useful in elucidating function, however applicability to translational research beyond …
been useful in elucidating function, however applicability to translational research beyond …
Double virus vector infection to the prefrontal network of the macaque brain
M Oguchi, M Okajima, S Tanaka, M Koizumi… - PLoS …, 2015 - journals.plos.org
To precisely understand how higher cognitive functions are implemented in the prefrontal
network of the brain, optogenetic and pharmacogenetic methods to manipulate the signal …
network of the brain, optogenetic and pharmacogenetic methods to manipulate the signal …
5-HT1B autoreceptors differentially modulate the expression of conditioned fear in a circuit-specific manner
Y Liu, MA Kelly, TJ Sexton, JF Neumaier - Neuroscience, 2015 - Elsevier
Located in the nerve terminals of serotonergic neurons, 5-HT 1B autoreceptors are poised to
modulate synaptic 5-HT levels with precise temporal and spatial control, and play an …
modulate synaptic 5-HT levels with precise temporal and spatial control, and play an …
DREADD'ed addiction: using designer receptors to delineate neural circuits underlying drug-seeking behaviors
SG Nair, D Smirnov, JF Neumaier - Designer Receptors Exclusively …, 2015 - Springer
One of the important problems in the treatment of addiction is the vulnerability of previously
addicted individuals to relapse to drug use months or even years after abstinence …
addicted individuals to relapse to drug use months or even years after abstinence …
[引用][C] Differential effects of pharmacogenetic activation of VTA and SN dopamine neurons on locomotion and feeding behaviour in rats
L Boekhoudt, JW de Jong, A Omrani, AE de Leeuw…