The RAS/MAP kinase and the RAS/PI3K/AKT pathways play a key role in the regulation of
proliferation, differentiation and survival. The induction of these pathways depends on …

Non-small cell lung cancer (NSCLC) is a devastating disease with poor prognosis. Systemic
chemotherapy has been the mainstay of treatment in advanced disease for many decades …

We previously elucidated the pleotropic role of solute carrier family A1 member 5 (SLC1A5)
as the primary transporter of glutamine (Gln), a modulator of cell growth and oxidative stress …

Aberrant expression of RNA-binding proteins has profound implications for cellular
physiology and the pathogenesis of human diseases such as cancer. We previously …

SOX2 overlapping transcript (SOX2OT) is a long non-coding RNA which harbors one of the
major regulators of pluripotency, SOX2 gene, in its intronic region. SOX2OT gene is mapped …

Introduction Gene amplification is an important genetic change in cancer cells. We
investigated the prevalence, clinicopathological characteristics, and prognostic value of …

Objectives Second primary lung cancers (SPLC) are not uncommon in survivors of
squamous cell head and neck cancer (HNSCC), and carry a worse prognosis than when …

The recent development of human genome studies has demonstrated the possibility of
alteration of several genes as oncogenic driver mutations of lung squamous cell carcinoma …

Purpose Colorectal polyps are generally believed to be the precursors of colorectal cancers
(CRC); however, the proportion and speed of progression differed widely in different subsets …

Adenocarcinoma (AC) and squamous cell carcinoma (SCC) of non–small cell lung
carcinoma (NSCLC) have different clinical presentations, morphologies, treatments, and …