Origin of cardiomyocytes in the adult heart
A Leri, M Rota, FS Pasqualini, P Goichberg… - Circulation …, 2015 - Am Heart Assoc
This review article discusses the mechanisms of cardiomyogenesis in the adult heart. They
include the re-entry of cardiomyocytes into the cell cycle; dedifferentiation of pre-existing …
include the re-entry of cardiomyocytes into the cell cycle; dedifferentiation of pre-existing …
Intracoronary autologous cardiac progenitor cell transfer in patients with hypoplastic left heart syndrome: the TICAP prospective phase 1 controlled trial
S Ishigami, S Ohtsuki, S Tarui, D Ousaka… - Circulation …, 2015 - Am Heart Assoc
Rationale: Hypoplastic left heart syndrome (HLHS) remains a lethal congenital cardiac
defect. Recent studies have suggested that intracoronary administration of autologous …
defect. Recent studies have suggested that intracoronary administration of autologous …
[HTML][HTML] Stem cell therapy and tissue engineering for correction of congenital heart disease
This review article reports on the new field of stem cell therapy and tissue engineering and
its potential on the management of congenital heart disease. To date, stem cell therapy has …
its potential on the management of congenital heart disease. To date, stem cell therapy has …
Cardiac extracellular matrix–fibrin hybrid scaffolds with tunable properties for cardiovascular tissue engineering
Solubilized cardiac extracellular matrix (ECM) is being developed as an injectable
therapeutic that offers promise for promoting cardiac repair. However, the ECM alone forms …
therapeutic that offers promise for promoting cardiac repair. However, the ECM alone forms …
Partially digested adult cardiac extracellular matrix promotes cardiomyocyte proliferation in vitro
C Williams, K Sullivan… - Advanced healthcare …, 2015 - Wiley Online Library
Stimulating or maintaining the proliferative capacity of postnatal mammalian cardiomyocytes
is a major challenge to cardiac regeneration. Previously, it is found that fetal cardiac …
is a major challenge to cardiac regeneration. Previously, it is found that fetal cardiac …
The emergence of stem cell therapy for patients with congenital heart disease
B Wehman, S Kaushal - Circulation research, 2015 - Am Heart Assoc
CD45− mononuclear cells obtained from myocardial biopsies. The CArdiosphere-Derived
aUtologous stem cElls to reverse ventricUlar dySfunction (CADUCEUS) trial was a …
aUtologous stem cElls to reverse ventricUlar dySfunction (CADUCEUS) trial was a …
[HTML][HTML] Simulated microgravity exerts an age-dependent effect on the differentiation of cardiovascular progenitors isolated from the human heart
TI Fuentes, N Appleby, M Raya, L Bailey, N Hasaniya… - PLoS …, 2015 - journals.plos.org
Microgravity has a profound effect on cardiovascular function, however, little is known about
the impact of microgravity on progenitors that reside within the heart. We investigated the …
the impact of microgravity on progenitors that reside within the heart. We investigated the …
[HTML][HTML] Celastrol, an oral heat shock activator, ameliorates multiple animal disease models of cell death
Protein homeostatic regulators have been shown to ameliorate single, loss-of-function
protein diseases but not to treat broader animal disease models that may involve cell death …
protein diseases but not to treat broader animal disease models that may involve cell death …
[HTML][HTML] Rescue of neonatal cardiac dysfunction in mice by administration of cardiac progenitor cells in utero
Striated preferentially expressed gene (Speg) is a member of the myosin light chain kinase
family. We previously showed that disruption of the Speg gene locus in mice leads to a …
family. We previously showed that disruption of the Speg gene locus in mice leads to a …
Cardiosphere-derived cells from pediatric end-stage heart failure patients have enhanced functional activity due to the heat shock response regulating the secretome
We have demonstrated that human neonatal cardiosphere-derived cells (CDCs) derived
from the young are more regenerative due to their robust secretome. However, it is unclear …
from the young are more regenerative due to their robust secretome. However, it is unclear …