Objective The relationship between sex/gender differences and autism has attracted a
variety of research ranging from clinical and neurobiological to etiological, stimulated by the …

Autism spectrum disorder is typical of the majority of neuropsychiatric syndromes in that it is
defined by signs and symptoms, rather than by aetiology. Not surprisingly, the causes of this …

Genetic and genomic approaches have implicated hundreds of genetic loci in
neurodevelopmental disorders and neurodegeneration, but mechanistic understanding …

Recent studies implicate chromatin modifiers in autism spectrum disorder (ASD) through the
identification of recurrent de novo loss of function mutations in affected individuals. ASD risk …

Intellectual disability, autism spectrum disorder, and epilepsy are prime examples of
neurodevelopmental disorders that collectively affect a significant percentage of the world …

Haploinsufficiency of the Shank3 gene, which encodes a scaffolding protein at glutamatergic
synapses, is a highly prevalent and penetrant risk factor for autism. Using combined …

Autism spectrum disorder (ASD) is defined by impaired social interaction and
communication accompanied by stereotyped behaviors and restricted interests. Although …

Despite considerable genetic heterogeneity underlying neurodevelopmental diseases, there
is compelling evidence that many disease genes will map to a much smaller number of …

Understanding the pathogenesis of neurodevelopmental disorders has proven to be
challenging. Using autism spectrum disorder (ASD) as a paradigmatic neurodevelopmental …

Autism spectrum disorders (ASDs) are characterized by phenotypic and genetic
heterogeneity. Our analysis of functional networks perturbed in ASD suggests that both …