Blood brain barrier: a challenge for effectual therapy of brain tumors

A Bhowmik, R Khan, MK Ghosh - BioMed research international, 2015 - Wiley Online Library
Brain tumors are one of the most formidable diseases of mankind. They have only a fair to
poor prognosis and high relapse rate. One of the major causes of extreme difficulty in brain …

Nanotechnology‐based drug delivery systems for melanoma antitumoral therapy: a review

RB Rigon, MH Oyafuso, AT Fujimura… - BioMed research …, 2015 - Wiley Online Library
Melanoma (MEL) is a less common type of skin cancer, but it is more aggressive with a high
mortality rate. The World Cancer Research Fund International (GLOBOCAN 2012) estimates …

Design of Hybrid MnO2‐Polymer‐Lipid Nanoparticles with Tunable Oxygen Generation Rates and Tumor Accumulation for Cancer Treatment

CR Gordijo, AZ Abbasi, MA Amini… - Advanced Functional …, 2015 - Wiley Online Library
Manganese dioxide (MnO2) nanoparticles (NPs) were discovered in previous work to be
effective in improving tumor oxygenation (hypoxia) and reducing H2O2 and acidity in the …

Gold nanoclusters‐based nanoprobes for simultaneous fluorescence imaging and targeted photodynamic therapy with superior penetration and retention behavior in …

C Zhang, C Li, Y Liu, J Zhang, C Bao… - Advanced Functional …, 2015 - Wiley Online Library
Gold nanoclusters (GNCs) attract increasing attention due to their potential applications in
sensing, catalysis, optoelectronics, and biomedicine. Herein, the formation of highly …

[HTML][HTML] Formulation and characterization of 5-Fluorouracil enteric coated nanoparticles for sustained and localized release in treating colorectal cancer

S Tummala, MNS Kumar, A Prakash - Saudi Pharmaceutical Journal, 2015 - Elsevier
Fluorouracil is used in the treatment of colorectal cancer along with oxaliplatin as first line
treatment, but it is having lack of site specificity and poor therapeutic effect. Also toxic effects …

Tetracycline-grafted PLGA nanoparticles as bone-targeting drug delivery system

H Wang, J Liu, S Tao, G Chai, J Wang… - International journal …, 2015 - Taylor & Francis
Purpose Nanoparticles (NPs) that target bone tissue were developed using poly (lactic-co-
glycolic acid)(PLGA) copolymers and tetracycline (TC)-based bone-targeting moieties …

An injectable drug-loaded hydrogel based on a supramolecular polymeric prodrug

L Xiong, Q Luo, Y Wang, X Li, Z Shen… - Chemical …, 2015 - pubs.rsc.org
We reported a novel injectable doxorubicin-loaded hydrogel based on host–guest
interaction and Schiff's base reaction. A supramolecular polymeric prodrug was prepared …

Nanoneurotherapeutics approach intended for direct nose to brain delivery

S Md, G Mustafa, S Baboota, J Ali - Drug development and …, 2015 - Taylor & Francis
Context: Brain disorders remain the world's leading cause of disability, and account for more
hospitalizations and prolonged care than almost all other diseases combined. The majority …

Bevacizumab loaded solid lipid nanoparticles prepared by the coacervation technique: preliminary in vitro studies

L Battaglia, M Gallarate, E Peira, D Chirio… - …, 2015 - iopscience.iop.org
Glioblastoma, the most common primary brain tumor in adults, has an inauspicious
prognosis, given that overcoming the blood–brain barrier is the major obstacle to the …

Overcoming the skin permeation barrier: challenges and opportunities

C Vitorino, J Sousa, A Pais - Current Pharmaceutical Design, 2015 - ingentaconnect.com
Stratum corneum (SC), the outermost layer of the skin, constitutes an excellent protective
physiological barrier, and is the main challenge in transdermal drug delivery. Many …