Neuroinflammation in Alzheimer's disease
Increasing evidence suggests that Alzheimer's disease pathogenesis is not restricted to the
neuronal compartment, but includes strong interactions with immunological mechanisms in …
neuronal compartment, but includes strong interactions with immunological mechanisms in …
TSPO is a REDOX regulator of cell mitophagy
J Gatliff, M Campanella - Biochemical Society transactions, 2015 - portlandpress.com
The mitochondrial 18-kDa translocator protein (TSPO) was originally discovered as a
peripheral binding site of benzodiazepines to be later described as a core element of …
peripheral binding site of benzodiazepines to be later described as a core element of …
Differentiation and quantification of inflammation, demyelination and axon injury or loss in multiple sclerosis
Axon injury/loss, demyelination and inflammation are the primary pathologies in multiple
sclerosis lesions. Despite the prevailing notion that axon/neuron loss is the substrate of …
sclerosis lesions. Despite the prevailing notion that axon/neuron loss is the substrate of …
[HTML][HTML] Evaluation of [11C]CB184 for imaging and quantification of TSPO overexpression in a rat model of herpes encephalitis
D Vállez Garcia, EFJ de Vries, J Toyohara… - European Journal of …, 2015 - Springer
Purpose Evaluation of translocator protein (TSPO) overexpression is considered an
attractive research tool for monitoring neuroinflammation in several neurological and …
attractive research tool for monitoring neuroinflammation in several neurological and …
Comparison of in vivo binding properties of the 18-kDa translocator protein (TSPO) ligands [18F]PBR102 and [18F]PBR111 in a model of excitotoxin-induced …
PD Callaghan, CA Wimberley, GL Rahardjo… - European journal of …, 2015 - Springer
Purpose The in vivo binding parameters of the novel imidazopyridine TSPO ligand [18 F]
PBR102 were assessed and compared with those of [18 F] PBR111 in a rodent model of …
PBR102 were assessed and compared with those of [18 F] PBR111 in a rodent model of …
Synthesis and in vitro characterization of novel fluorinated derivatives of the TSPO 18 kDa ligand SSR180575
A Damont, F Marguet, F Puech, F Dollé - European Journal of Medicinal …, 2015 - Elsevier
Abstract SSR180575 (1) is a high-affinity (0.83 nM) TSPO 18 kDa ligand belonging to the
pyridazino [4, 5-b] indole-1-acetamides family. Herein we describe the synthesis and in vitro …
pyridazino [4, 5-b] indole-1-acetamides family. Herein we describe the synthesis and in vitro …
PET Imaging of Mild Traumatic Brain Injury and Whiplash Associated Disorder
DV García - 2015 - research.rug.nl
Traumatic brain injury is the leading cause of brain injury in our society with 235 per 100,000
inhabitants per year in the European Union and about 500 per 100,000 inhabitants per year …
inhabitants per year in the European Union and about 500 per 100,000 inhabitants per year …