Maintenance of the highly organized striated muscle tissue requires a cell-wide dynamic
network that through interactions with all vital cell structures, provides an effective …

Desmin is a muscle-specific type III intermediate filament essential for proper muscular
structure and function. In human, mutations affecting desmin expression or promoting its …

Tumor necrosis factor-α (TNF-α), one of the major stress-induced proinflammatory cytokines,
is upregulated in the heart after tissue injury,, and its sustained expression can contribute to …

This study demonstrates that the association of mitochondria with vimentin intermediate
filaments (VIFs) measurably increases their membrane potential. This increase is detected …

Mutations of the human desmin gene on chromosome 2q35 cause autosomal dominant,
autosomal recessive and sporadic forms of protein aggregation myopathies and …

Left ventricular (LV) volume overload (VO) results in cardiomyocyte oxidative stress and
mitochondrial dysfunction. Because mitochondria are both a source and target of ROS, we …

Patients with peripheral artery disease (PAD) develop a myopathy in their ischemic lower
extremities, which is characterized by myofiber degeneration, mitochondrial dysfunction and …

The congenital myopathies are a diverse group of genetic skeletal muscle diseases, which
typically present at birth or in early infancy. There are multiple modes of inheritance and …

ABSTRACT A fundamental requirement of cells is their ability to transduce and interpret their
mechanical environment. This ability contributes to regulation of growth, differentiation and …

Intrauterine growth restriction (IUGR) is associated with an increased risk of developing
obesity, insulin resistance and cardiovascular disease. However, its effect on energetics in …