Tuberculosis (TB) lesions are extremely complex and dynamic. Here, we review the multiple
types and fates of pulmonary lesions that form following infection by M ycobacterium …

The recent accelerated approval for use in extensively drug-resistant and multidrug-resistant-
tuberculosis (MDR-TB) of two first-in-class TB drugs, bedaquiline and delamanid, has …

Mycobacterium tuberculosis (Mtb) relies on a specialized set of metabolic pathways to
support growth in macrophages. By conducting an extensive, unbiased chemical screen to …

Host-directed therapies are a relatively new and promising approach to treatment of
tuberculosis. Modulation of specific host immune pathways, including those that impact …

A central tenet of tuberculosis pathogenesis is that caseous necrosis leads to extracellular
matrix destruction and bacterial transmission. We reconsider the underlying mechanism of …

Metabolism underpins the physiology and pathogenesis of Mycobacterium tuberculosis.
However, although experimental mycobacteriology has provided key insights into the …

The formation and maintenance of granulomas is central to the host response to
Mycobacterium tuberculosis (Mtb) infection. It is widely accepted that the lungs of patients …

Recent studies are revealing astonishing heterogeneity in host-pathogen interactions
occurring simultaneously within the same host tissue. As highlighted in this review, growing …

Lipid droplets exist in virtually every cell type, ranging not only from mammals to plants, but
also to eukaryotic and prokaryotic unicellular organisms such as D ictyostelium and bacteria …

Mycobacterium tuberculosis is responsible for about 9 million new tuberculosis (TB) cases
per year and 2 billion latent TB infections (LTBI) worldwide. 1, 2 Most of active TB is owing to …