Imaging tumour hypoxia with positron emission tomography

IN Fleming, R Manavaki, PJ Blower, C West… - British journal of …, 2015 - nature.com
Hypoxia, a hallmark of most solid tumours, is a negative prognostic factor due to its
association with an aggressive tumour phenotype and therapeutic resistance. Given its …

Advances in radiotherapy for head and neck cancer

V Grégoire, JA Langendijk, S Nuyts - Journal of Clinical Oncology, 2015 - ascopubs.org
Over the last few decades, significant improvements have been made in the radiotherapy
(RT) treatment of head and neck malignancies. The progressive introduction of intensity …

Serial [18F]-fluoromisonidazole PET during radiochemotherapy for locally advanced head and neck cancer and its correlation with outcome

NE Wiedenmann, S Bucher, M Hentschel, M Mix… - Radiotherapy and …, 2015 - Elsevier
Purpose The aim was to assess changes of tumour hypoxia during primary
radiochemotherapy (RCT) for head and neck cancer (HNC) and to evaluate their …

PET/MR in cancers of the head and neck

MA Queiroz, MW Huellner - Seminars in nuclear medicine, 2015 - Elsevier
One early application of PET/MRI in clinical practice may be the imaging of head and neck
cancers. This is because the morphologic imaging modalities, CT and MR, are recognized …

Intravoxel incoherent motion imaging kinetics during chemoradiotherapy for human papillomavirus‐associated squamous cell carcinoma of the oropharynx …

Y Ding, JD Hazle, ASR Mohamed, SJ Frank… - NMR in …, 2015 - Wiley Online Library
This study aims to identify the temporal kinetics of intravoxel incoherent motion (IVIM) MRI in
patients with human papillomavirus‐associated (HPV+) oropharyngeal squamous cell …

Spatial distribution of FMISO in head and neck squamous cell carcinomas during radio-chemotherapy and its correlation to pattern of failure

S Zschaeck, R Haase, N Abolmaali, R Perrin… - Acta …, 2015 - Taylor & Francis
Background. Tumour hypoxia can be measured by FMISO-PET and negatively impacts local
tumour control in patients with head and neck squamous cell carcinoma (HNSCC) …

[PDF][PDF] Current preclinical and clinical applications of hypoxia PET imaging using 2-nitroimidazoles

SG Peeters, CM Zegers, A Yaromina… - QJ Nucl Med Mol …, 2015 - researchgate.net
Hypoxia is a common characteristic of solid tumors and is associated with poor prognosis.
Positron emission tomography (PET) can visualize tumor hypoxia in a non-invasive, 3 …

Alterations in anatomic and functional imaging parameters with repeated FDG PET-CT and MRI during radiotherapy for head and neck cancer: a pilot study

M Subesinghe, AF Scarsbrook, S Sourbron, DJ Wilson… - BMC cancer, 2015 - Springer
Background The use of imaging to implement on-treatment adaptation of radiotherapy is a
promising paradigm but current data on imaging changes during radiotherapy is limited …

The role of PET-CT in radiotherapy planning of solid tumours

S Jelercic, M Rajer - Radiology and oncology, 2015 - sciendo.com
Background. PET-CT is becoming more and more important in various aspects of oncology.
Until recently it was used mainly as part of diagnostic procedures and for evaluation of …

PET imaging in head and neck cancer patients to monitor treatment response: a future role for EGFR-targeted imaging

LK van Dijk, OC Boerman, JHAM Kaanders… - Clinical Cancer …, 2015 - AACR
Approximately 50,000 new cases of head and neck squamous cell carcinoma (HNSCC) are
diagnosed worldwide each year and subsequently treated with surgery, chemotherapy …