Sažetak Coumarins, natural or synthetic, due to their wide range of biological activities, have
become an interesting subject of investigation for many researchers. Coumarin scaffold has …

Triazole-based heterocycles have previously been shown to possess significant anticancer
activity in various tumor models. In the present study, we attached a 1, 2, 3-triazole moiety to …

Rationale: Alveolar macrophages (AMs) play a key role in host defense to inhaled bacterial
pathogens, in part by secreting inflammatory mediators. Cystic fibrosis (CF) airways exhibit a …

Cancer is a leading cause of death in developed countries and second cause in developing
countries. Herein we are reporting the synthesis of novel bisbenzimidazole derivatives and …

Elevated activity of methionyl-tRNA synthetase (MRS) in many cancers renders it a possible
drug target in this disease area, as well as in a series of parasitic diseases. In the present …

Condensed-bicyclic triazolo-thiadiazoles were synthesized via an efficient “green” catalyst
strategy and identified as effective inhibitors of PTP1B in vitro. The lead compound, 6-(2 …

In the present study, we used solution combustion synthesis-bismuth oxide (Bi 2 O 3) as
catalyst for the simple and efficient synthesis of 1, 2-oxazine based derivatives of 6-fluoro-3 …

Cystic fibrosis (CF) is a monogenetic disease caused mostly by the F508del mutation, a
deletion of phenylalanine at position 508 of the CF transmembrane conductance regulator …

In this work, we describe the 'green'synthesis of novel 6-(adamantan-1-yl)-2-substituted-
imidazo [2, 1-b][1, 3, 4] thiadiazoles (AITs) by ring formation reactions using 1-(adamantan-1 …

Malaria parasites are currently gaining drug-resistance rapidly, across countries and
continents. Hence, the discovery and development of novel chemical scaffolds, with superior …