The retina is a highly sophisticated piece of the neural machinery that begins the translation
of incoming light signals into meaningful visual information. Several degenerative diseases …

Laminin-211 is a major constituent of the skeletal muscle basement membrane, exerting its
biological functions by binding to cell surface receptors integrin α7β1 and dystroglycan (the …

The neuromuscular junction (NMJ) is the synaptic contact between motoneurons and
muscle, where neurotransmission results in the contraction of the muscle fibres. The basal …

Merosin deficient congenital muscular dystrophy type 1A (MDC1A) is caused by the loss of
laminin-211 and laminin-221 heterotrimers which are most abundant in skeletal and cardiac …

Duchenne muscular dystrophy (DMD) is a catastrophic X-linked neuromuscular disease that
affects 1 in every 5000 males. DMD is caused by mutations in the dystrophin gene which …