Cyclooxygenases (COX-1 and COX-2) are key enzymes in several physiopathological
processes. Many adverse drugs reactions to NSAIDs are attributable to COX-inhibition. The …

Purpose Although the exact mechanisms that lead to degenerative disc disease (DDD) are
not well understood, a significant genetic influence has been found. Focusing on DDD that …

There is considerable interindividual variation in the response to antiplatelet and
anticoagulant therapies. It has been proposed that this variability in drug response may be …

Background: Previous studies suggested the single nucleotide polymorphism (SNP) of COX-
2-765G> C (rs20417) is associated with coronary artery disease (CAD), but the results were …

阿司匹林是一种广泛应用于临床的抗血小板药物, 临床试验显示5%~ 65% 的脑卒中患者对
阿司匹林治疗不敏感, 即为阿司匹林抵抗. 导致阿司匹林抵抗存在许多潜在因素 …

Celecoxib is the only FDA selective cyclooxygenase-2 (COX-2) inhibitor approved
nowadays. Studies showed that its therapeutic efficacy and toxicity may be related to inter …