The idea that memory is stored in the brain as physical alterations goes back at least as far
as Plato, but further conceptualization of this idea had to wait until the 20 th century when …

A large body of data from human and animal studies using psychological, recording,
imaging, and lesion techniques indicates that recognition memory involves at least two …

Over recent years, accumulated evidence suggests that autophagy induction is protective in
animal models of a number of neurodegenerative diseases. Intense research in the field has …

The present study examined why perirhinal cortex lesions in rats impair the spontaneous
ability to select novel objects in preference to familiar objects, when both classes of object …

Rats with perirhinal cortex lesions received multiple object recognition trials within a
continuous session to examine whether they show false memories. Experiment 1 focused on …

Chronic intermittent hypoxia (CIH) is commonly seen in patients with obstructive sleep
apnea, and has been hypothesized to underlie the neurocognitive dysfunction in these …

Attention deficits in Alzheimer's disease can exacerbate its other cognitive symptoms, yet
relevant disruptions of key prefrontal circuitry are not well understood. Here, in the …

Aging is accompanied by an increase in false alarms on recognition tasks, and these false
alarms increase with repetition in older people (but not in young people). Traditionally, this …

This dissertation investigates the mechanisms underlying pattern separation, using rodent
models and behavioural tasks that assess the use of representations for similar stimuli …

Recognition memory is the ability to distinguish novel from familiar stimuli. This thesis
explores opposing models of recognition memory that alternatively assume that the …