T cell antigen receptor recognition of antigen-presenting molecules
The Major Histocompatibility Complex (MHC) locus encodes classical MHC class I and MHC
class II molecules and nonclassical MHC-I molecules. The architecture of these molecules is …
class II molecules and nonclassical MHC-I molecules. The architecture of these molecules is …
Evolving models of the immunopathogenesis of T cell–mediated drug allergy: The role of host, pathogens, and drug response
Immune-mediated (IM) adverse drug reactions (ADRs) are an underrecognized source of
preventable morbidity, mortality, and cost. Increasingly, genetic variation in the HLA loci is …
preventable morbidity, mortality, and cost. Increasingly, genetic variation in the HLA loci is …
Clinical role of human leukocyte antigen in health and disease
YM Mosaad - Scandinavian journal of immunology, 2015 - Wiley Online Library
Most of the genes in the major histocompatibility complex (MHC) region express high
polymorphism that is fundamental for their function. The most important function of human …
polymorphism that is fundamental for their function. The most important function of human …
Revisiting the arthritogenic peptide theory: quantitative not qualitative changes in the peptide repertoire of HLA–B27 allotypes
RB Schittenhelm, TCCLK Sian… - Arthritis & …, 2015 - Wiley Online Library
Objective The association of HLA–B27 with spondyloarthropathy is one of the strongest
documented for any autoimmune disease. A common hypothesis for this association is the …
documented for any autoimmune disease. A common hypothesis for this association is the …
T cell–mediated hypersensitivity reactions to drugs
The immunological mechanisms driving delayed hypersensitivity reactions (HSRs) to drugs
mediated by drug-reactive T lymphocytes are exemplified by several key examples and their …
mediated by drug-reactive T lymphocytes are exemplified by several key examples and their …
[HTML][HTML] New genetic findings lead the way to a better understanding of fundamental mechanisms of drug hypersensitivity
M Pirmohamed, DA Ostrov, BK Park - Journal of Allergy and Clinical …, 2015 - Elsevier
Drug hypersensitivity reactions are an important clinical problem for both health care and
industry. Recent advances in genetics have identified a number of HLA alleles associated …
industry. Recent advances in genetics have identified a number of HLA alleles associated …
[HTML][HTML] Pathogenesis and diagnosis of delayed-type drug hypersensitivity reactions, from bedside to bench and back
R Schrijvers, L Gilissen, AM Chiriac… - Clinical and translational …, 2015 - Springer
Drug hypersensitivity reactions (DHR) have been present since the advent of drugs. In
particular T-cell mediated delayed-type hypersensitivity reactions represent a …
particular T-cell mediated delayed-type hypersensitivity reactions represent a …
[HTML][HTML] Drug hypersensitivity: how drugs stimulate T cells via pharmacological interaction with immune receptors
WJ Pichler, J Adam, S Watkins, N Wuillemin… - International archives of …, 2015 - karger.com
Small chemicals like drugs tend to bind to proteins via noncovalent bonds, eg hydrogen
bonds, salt bridges or electrostatic interactions. Some chemicals interact with other …
bonds, salt bridges or electrostatic interactions. Some chemicals interact with other …
Parsing interindividual drug variability: an emerging role for systems pharmacology
RM Turner, BK Park… - … Reviews: Systems Biology …, 2015 - Wiley Online Library
There is notable interindividual heterogeneity in drug response, affecting both drug efficacy
and toxicity, resulting in patient harm and the inefficient utilization of limited healthcare …
and toxicity, resulting in patient harm and the inefficient utilization of limited healthcare …