PI3Ks regulate several key events in the inflammatory response to damage and infection.
There are four Class I PI3K isoforms (PI3Kα, β, γ, δ), three Class II PI3K isoforms (PI3KC2α …

Highlights•Preclinical studies support us of PI3K inhibitors in autoimmunity and
inflammation.•First in class PI3K inhibitor has been approved for treatment of B cell …

The risk of onset of cancer is influenced by poorly controlled chronic inflammatory
processes. Inflammatory diseases related to cancer development include inflammatory …

Optimization of lead compound 1, through extensive use of structure-based design and a
focus on PI3Kδ potency, isoform selectivity, and inhaled PK properties, led to the discovery …

Colorectal cancer, unlike many other malignancies, may be preventable. Recent studies
have demonstrated an inverse association between nut consumption and incidence of colon …

Current treatment strategies for chronic lymphocytic leukemia (CLL) involve a combination of
conventional chemotherapeutics, monoclonal antibodies, and targeted signaling inhibitors …

Increasing evidences suggest that PI3K/AKT pathway plays an important role in the
pathogenesis of inflammatory diseases such as acute pancreatitis. However, the exact effect …

Introduction Despite the broad spectrum of antirheumatic drugs, RA is still not well controlled
in up to 30-50% of patients. Inhibition of JAK kinases by means of the pan-JAK inhibitor …

Neutrophils play critical roles in innate immunity and host defense. However, excessive
neutrophil accumulation or hyper‐responsiveness of neutrophils can be detrimental to the …

Chronic lymphocytic leukemia (CLL) is the most common leukemia among adults in the
Western world. Autophagy is a highly conserved process in eukaryotic cells. In CLL …