Drug discovery and development is a high-risk, expensive endeavor and it commonly takes
about 10− 15 years to obtain marketing approval from project inception. 1 Research efforts …

This review is the sixth update of the original article published in 1999 on the application of
MALDI mass spectrometry to the analysis of carbohydrates and glycoconjugates and brings …

In pharmaceutical research, understanding the biodistribution, accumulation and
metabolism of drugs in tissue plays a key role during drug discovery and development. In …

Initiatives to support the sustainable development of the nanotechnology sector have led to
rapid growth in research on the environmental fate, hazards and risk of engineered …

Mass spectrometry imaging (MSI) has become a powerful and successful tool in the context
of biomarker detection especially in recent years. This emerging technique is based on the …

Mass spectrometry imaging (MSI) uses biomolecular mass spectrometry techniques to
simultaneously record the distributions of molecules directly from tissue samples [1] and …

Colistin and polymyxin B are effective treatment options for Gram-negative resistant bacteria
but are used as last-line therapy due to their dose-limiting nephrotoxicity. A critical factor in …

This retrospective on imaging mass spectrometry describes the coming of age of an
approach that has matured from an innovative technological development to a broadly …

Matrix deposition on agar-based microbial colonies for MALDI imaging mass spectrometry is
often complicated by the complex media on which microbes are grown. This Application …

Since biology is by and large a 3-dimensional phenomenon, it is hardly surprising that 3D
imaging has had a significant impact on many challenges in the life sciences. Imaging mass …