Chronic pain is an international health issue of immense importance that is influenced by
both physical and psychological factors. Opioids are useful in treating chronic pain but have …

Background: Opioid-induced hyperalgesia is a clinical syndrome whereby patients on long-
term opioids become more sensitive to pain while taking opioids. Opioid-induced …

BACKGROUND Chronic pain and opioid consumption may trigger diffuse hyperalgesia, but
their relative contributions to pain vulnerability remain unclear. OBJECTIVES To assess …

The primary afferent nociceptor was used as a model system to study mechanisms of pain
induced by chronic opioid administration. Repeated intradermal injection of the selective mu …

The hyperalgesic effects of long-term opioid use in community-dwelling adults with chronic
pain have not been widely reported. Therefore, the primary aim of this study was to …

Objective The aim of this study was to compare the sensitivity to experimental pain of chronic
pain patients on opioid therapy vs chronic pain patients on non-opioid therapy and healthy …

Background: Neuropathic pain is a condition resulting from injury to the peripheral and/or
central nervous system. Despite extensive research over the last several decades …

Multimodal analgesia was proposed 25 years ago as a way of improving postoperative pain
management. 9 The main objectives of combining nonopioid analgesics with opioid …

Highlights•Chronic pain is a growing public health concern.•There has been a dramatic
increase in prescriptions of analgesic opioids in the United States.•Psychiatric co-morbidity …

Background Patients with opioid use disorders on opioid agonist therapy (OAT) have lower
pain tolerance compared to controls. While chronic viral infections such as HCV and HIV …