Background Combined immunodeficiencies are marked by inborn errors of T-cell immunity
in which the T cells that are present are quantitatively or functionally deficient. Impaired …

Sustained neuroinflammation mediated by resident microglia is recognized as a key
pathophysiological contributor to many neurodegenerative diseases, including Parkinson's …

Background Melanoma is the most fatal skin cancer displaying a high degree of molecular
heterogeneity. Phenotype switching is a mechanism that contributes to melanoma …

Lymphocyte signaling cascades responsible for anti-tumor cytotoxicity and inflammatory
cytokine production must be tightly regulated in order to control an immune response …

Natural killer (NK) immune cells mediate antibody-dependent cellular cytotoxicity (ADCC) by
aggregating FcγRIIIA/CD16, contributing significantly to the therapeutic effect of CD20 …

Abstract HLA-null cell lines [721.221 (henceforth, 721) and K562] are often used to study NK
cell activation. NK cells are innate immune lymphocytes that express a variety of …

Absence of MHC class I expression is an important mechanism by which NK cells recognize
a variety of target cells, yet the pathways underlying “missing‐self” recognition, including the …

Despite progress in understanding enteric inflammation, current therapies, although
effective in many patients with inflammatory bowel disease (IBD), have significant side …

Adaptor proteins mediate protein− protein interactions in signal transduction cascades.
These signaling molecules are organized in multimolecular complexes that translate …

The analysis of gene function in mature and activated natural killer cells has been hampered
by the lack of model systems for Cre-mediated recombination in these cells. Here we have …