Lysosomes are acidic compartments filled with more than 60 different types of hydrolases.
They mediate the degradation of extracellular particles from endocytosis and of intracellular …

Abstract Members of the Transient Receptor Potential-Mucolipin (TRPML) constitute a family
of evolutionarily conserved cation channels that function predominantly in endolysosomal …

Summary Presenilin 1 (PS1) deletion or Alzheimer's disease (AD)-linked mutations disrupt
lysosomal acidification and proteolysis, which inhibits autophagy. Here, we establish that …

The second messenger NAADP triggers Ca2+ release from endo‐lysosomes. Although two‐
pore channels (TPC s) have been proposed to be regulated by NAADP, recent studies have …

Two-pore channels (TPCs) are evolutionarily important members of the voltage-gated ion
channel superfamily. TPCs localize to acidic Ca2+ stores within the endolysosomal system …

To elucidate new functions of sphingosine (Sph), we demonstrate that the spontaneous
elevation of intracellular Sph levels via caged Sph leads to a significant and transient …

Since the discovery of the Ca 2+ mobilizing effects of the pyridine nucleotide metabolite,
nicotinic acid adenine dinucleotide phosphate (NAADP), this molecule has been …

Acidic Ca 2+ stores refer to a collection of H+-and Ca 2+-rich organelles involved in Ca 2+
signalling across taxonomic kingdoms. They include lysosomes, lysosome-related …

Ca 2+-permeable type 2 two-pore channels (TPC2) are lysosomal proteins required for
nicotinic acid adenine dinucleotide phosphate (NAADP)-evoked Ca 2+ release in many …

Acidic organelles such as lysosomes serve as non-canonical Ca 2+ stores. The Ca 2+
mobilising messenger NAADP is thought to trigger local Ca 2+ release from such stores …