The glycosaminoglycan hyaluronan (HA), a major component of extracellular matrices, and
cell surface receptors of HA have been proposed to have pivotal roles in cell proliferation …

Receptors of the innate immune system detect conserved determinants of microbial and viral
origin. Activation of these receptors initiates signaling events that culminate in an effective …

The epithelial surfaces of the lungs are in direct contact with the environment and are
subjected to dynamic physical forces as airway tubes and alveoli are stretched and …

Macrophages are the most numerous immune-cells present in the lung environment under
homoeostatic conditions and are ideally positioned to dictate the innate defence of the …

The acute respiratory distress syndrome (ARDS) is a form of severe hypoxemic respiratory
failure that is characterized by inflammatory injury to the alveolar capillary barrier, with …

Hyaluronan signaling properties are unique among other biologically active molecules, that
they are apparently not influenced by postsynthetic molecular modification, but by …

Aims Superficial erosion of atheromata causes many acute coronary syndromes, but arises
from unknown mechanisms. This study tested the hypothesis that Toll-like receptor-2 (TLR2) …

Rationale: Idiopathic pulmonary fibrosis (IPF) is a devastating lung disease of unknown
etiology. The genes TOLLIP and MUC5B play important roles in lung host defense, which is …

Hyaluronan (HA) is a prominent component of the extracellular matrix at many sites of
chronic inflammation, including type 1 diabetes (T1D), multiple sclerosis, and numerous …

Interstitial lung disease (ILD) encompasses a large and diverse group of pathological
conditions that share similar clinical, radiological and pathological manifestations, despite …