The first mammalian Wnt to be discovered, Wnt-1, was found to be essential for the
development of a large part of the mouse brain over 25 years ago. We have since learned …

Wnts are secreted glycoproteins that play multiple roles in early development, including the
differentiation of precursor cells. During this period, gradients of Wnts and other morphogens …

Objective To define whether anti‐ribosomal P (anti‐P) autoantibodies from patients with
neuropsychiatric systemic lupus erythematosus (NPSLE) impair the function of hippocampal …

Alzheimer's disease (AD) is the most common neurodegenerative disorder and is
characterized by progressive memory loss and cognitive decline. One of the hallmarks of AD …

Wnt signaling has a well-established role as a regulator of nervous system development, but
its role in the maintenance and regulation of established synapses in the mature brain …

Stem cells are a powerful resource for cell‐based transplantation therapies, but
understanding of stem cell differentiation at the molecular level is not clear yet. We …

Amyloid-β (Aβ) oligomers are a key factor in Alzheimer's disease (AD)-associated synaptic
dysfunction. Aβ oligomers block the induction of hippocampal long-term potentiation (LTP) in …

The morphology of the dendritic tree is critical to neuronal function and neural circuit wiring.
Several Wnt family members have been demonstrated to play important roles in dendrite …

Amyloid-β oligomers (Aβo) play a major role in the synaptic dysfunction of Alzheimer's
disease (AD). Neuroligins are postsynaptic cell-adhesion molecules, that share an …

Although the neurotoxicity of amyloid β (Aβ) protein in Alzheimer's disease (AD) has been
reported widely, the exact molecular mechanism underlying the Aβ-induced synaptic …