Focal segmental glomerulosclerosis (FSGS) describes both a common lesion in progressive
kidney disease, and a disease characterized by marked proteinuria and podocyte injury …

Diabetic nephropathy is a leading cause of end stage renal disease and its occurance is
increasing worldwide. The most effective treatment strategy for the condition is intensive …

The glomerulus is a highly specialized capillary tuft, which under pressure filters large
amounts of water and small solutes into the urinary space, while retaining albumin and large …

Primary cilium is an organelle that plays significant roles in a number of cellular functions
ranging from cell mechanosensation, proliferation, and differentiation to apoptosis …

The aged population suffers increased morbidity and higher mortality in response to
episodes of acute kidney injury (AKI). Aging is associated with telomere shortening, and …

Background/Aims: Autophagy is a dynamic catabolic process that maintains cellular
homeostasis. Whether it plays a role in promoting cell survival or cell death in the process of …

Background Heat shock protein beta-1 (HSPB1, also known as HSP27) is a small heat
shock protein involved in many cellular processes and reportedly protects cells against …

Podocytes play an important role in the pathogenesis and progression of
glomerulosclerosis. Recent studies indicate that aldosterone/mineralocorticoid receptor …

Motile and primary cilia (PC) are microtubule-based structures located at the cell surface of
many cell types. Cilia govern cellular functions ranging from motility to integration of …

Diabetic kidney disease is the leading worldwide cause of end stage kidney disease and a
growing public health challenge. The diabetic kidney is exposed to many environmental …