Crosstalk between the nociceptive and immune systems in host defence and disease
Nociceptors and immune cells both protect the host from potential threats to homeostasis.
There is growing evidence for bidirectional signalling between these two systems, and the …
There is growing evidence for bidirectional signalling between these two systems, and the …
TRPA1 as a drug target—promise and challenges
J Chen, DH Hackos - Naunyn-Schmiedeberg's archives of pharmacology, 2015 - Springer
The transient receptor potential ankyrin 1 (TRPA1) channel is a nonselective cation channel
belonging to the superfamily of transient receptor potential (TRP) channels. It is …
belonging to the superfamily of transient receptor potential (TRP) channels. It is …
The regulation of immunological processes by peripheral neurons in homeostasis and disease
J Ordovas-Montanes, S Rakoff-Nahoum, S Huang… - Trends in …, 2015 - cell.com
The nervous system and the immune system are the principal sensory interfaces between
the internal and external environment. They are responsible for recognizing, integrating, and …
the internal and external environment. They are responsible for recognizing, integrating, and …
Antibiotic-induced dysbiosis alters host-bacterial interactions and leads to colonic sensory and motor changes in mice
M Aguilera, M Cerdà-Cuéllar, V Martínez - Gut microbes, 2015 - Taylor & Francis
Alterations in the composition of the commensal microbiota (dysbiosis) seem to be a
pathogenic component of functional gastrointestinal disorders, mainly irritable bowel …
pathogenic component of functional gastrointestinal disorders, mainly irritable bowel …
The G protein–coupled receptor–transient receptor potential channel axis: molecular insights for targeting disorders of sensation and inflammation
Sensory nerves are equipped with receptors and ion channels that allow them to detect and
respond to diverse chemical, mechanical, and thermal stimuli. These sensory proteins …
respond to diverse chemical, mechanical, and thermal stimuli. These sensory proteins …
Sensory TRP channels: the key transducers of nociception and pain
Peripheral detection of nociceptive and painful stimuli by sensory neurons involves a
complex repertoire of molecular detectors and/or transducers on distinct subsets of nerve …
complex repertoire of molecular detectors and/or transducers on distinct subsets of nerve …
Molecular and cellular mechanisms that initiate pain and itch
Somatosensory neurons mediate our sense of touch. They are critically involved in
transducing pain and itch sensations under physiological and pathological conditions, along …
transducing pain and itch sensations under physiological and pathological conditions, along …
[HTML][HTML] Vinpocetine reduces lipopolysaccharide-induced inflammatory pain and neutrophil recruitment in mice by targeting oxidative stress, cytokines and NF-κB
KW Ruiz-Miyazawa, FA Pinho-Ribeiro… - Chemico-biological …, 2015 - Elsevier
In response to lipopolysaccharide (LPS), tissue resident macrophages and recruited
neutrophils produce inflammatory mediators through activation of Toll-like receptor 4 …
neutrophils produce inflammatory mediators through activation of Toll-like receptor 4 …
Polysulfide evokes acute pain through the activation of nociceptive TRPA1 in mouse sensory neurons
Y Hatakeyama, K Takahashi, M Tominaga… - Molecular …, 2015 - journals.sagepub.com
Background Hydrogen sulfide (H2S) is oxidized to polysulfide. Recent reports show that this
sulfur compound modulates various biological functions. We have reported that H2S is …
sulfur compound modulates various biological functions. We have reported that H2S is …
Vascular endothelial growth factor-A165b prevents diabetic neuropathic pain and sensory neuronal degeneration
Diabetic peripheral neuropathy affects up to half of diabetic patients. This neuronal damage
leads to sensory disturbances, including allodynia and hyperalgesia. Many growth factors …
leads to sensory disturbances, including allodynia and hyperalgesia. Many growth factors …