There is increasing evidence of prodromal manifestation of neuropsychiatric symptoms in a
variety of neurodegenerative diseases such as Parkinson's disease (PD) and Huntington's …

As the population steadily ages, dementia, in all its forms, remains a great societal
challenge. Yet, our knowledge of their etiology remains rather limited. To this end, genetic …

General cognitive function is substantially heritable across the human life course from
adolescence to old age. We investigated the genetic contribution to variation in this …

The very long (VL) poly-T variant at rs10524523 (“523”) of the TOMM40 gene may hasten
the onset of late-onset Alzheimer's disease (LOAD) and induce more profound cognitive …

This article investigates late-onset cognitive impairment using neuroimaging and genetics
biomarkers for Alzheimer's Disease Neuroimaging Initiative (ADNI) participants. Eight …

In Alzheimer's disease (AD), approximately 10–20% of direct costs are associated with
pharmacological treatment. Pharmacogenomics account for 30–90% variability in …

We previously reported TOMM40 to be significantly down-regulated in whole blood of
Alzheimer's disease (AD) subjects at baseline and after one-year. In this longitudinal follow …

Introduction We recently showed that tagging single-nucleotide polymorphisms across the
SNCA locus were significantly associated with increased risk for Lewy body (LB) pathology …

A previous study showed that, in carriers of the apolipoprotein E (APOE) genotype ε3/ε3 or
ε3/ε4, the presence of a very long (VL) polyT repeat allele in “translocase of outer …

There have been advances in the genetics of sIBM over the past 2 years facilitated by the
use of next-generation sequencing. Genes that cause hereditary IBM, which has clinical or …