Accessorizing and anchoring the LINC complex for multifunctionality

W Chang, HJ Worman, GG Gundersen - Journal of Cell Biology, 2015 - rupress.org
The linker of nucleoskeleton and cytoskeleton (LINC) complex, composed of outer and inner
nuclear membrane Klarsicht, ANC-1, and Syne homology (KASH) and Sad1 and UNC-84 …

Making the LINC: SUN and KASH protein interactions

DI Kim, B KC, KJ Roux - Biological Chemistry, 2015 - degruyter.com
Cell nuclei are physically integrated with the cytoskeleton through the linker of
nucleoskeleton and cytoskeleton (LINC) complex, a structure that spans the nuclear …

Nesprins anchor kinesin-1 motors to the nucleus to drive nuclear distribution in muscle cells

MH Wilson, ELF Holzbaur - Development, 2015 - journals.biologists.com
During skeletal muscle development, nuclei move dynamically through myotubes in a
microtubule-dependent manner, driven by the microtubule motor protein kinesin-1. Loss of …

[HTML][HTML] LINC'ing form and function at the nuclear envelope

P Meinke, EC Schirmer - FEBS letters, 2015 - Elsevier
The nuclear envelope is an amazing piece of engineering. On one hand it is built like a
mediaeval fortress with filament systems reinforcing its membrane walls and its double …

Do lamin A and lamin C have unique roles?

R Al-Saaidi, P Bross - Chromosoma, 2015 - Springer
The A-type lamins, lamin A and lamin C, generated from a single gene, LMNA, are major
structural components of the nuclear lamina. The two alternative splice products have mostly …

[HTML][HTML] Nesprin‑1 has key roles in the process of mesenchymal stem cell differentiation into cardiomyocyte‑like cells in vivo and in vitro

W Yang, H Zheng, Y Wang… - Molecular medicine …, 2015 - spandidos-publications.com
The aim of the present study was to investigate the expression of nesprin‑1 protein in MSCs
and its effects on the differentiation of rat bone‑marrow mesenchymal stem cells (MSCs) …

Inner nuclear membrane protein LEM-2 is required for correct nuclear separation and morphology in C. elegans

A Morales-Martínez, A Dobrzynska… - Journal of cell …, 2015 - journals.biologists.com
The inner nuclear membrane proteins emerin and LEMD2 have both overlapping and
separate functions in regulation of nuclear organization, gene expression and cell …

[PDF][PDF] Nucleus to synapse Nesprin1 railroad tracks direct synapse maturation through RNA localization

M Packard, V Jokhi, B Ding, J Ashley, V Budnik - Neuron, 2015 - cell.com
An important mechanism underlying synapse development and plasticity is the localization
of mRNAs that travel from the nucleus to synaptic sites. Here we demonstrate that the giant …

Role of structural flexibility in the evolution of emerin

J Yuan, B Xue - Journal of Theoretical Biology, 2015 - Elsevier
Emerin is a short inner nuclear membrane protein with an LEM-domain at the N-terminal
end and a transmembrane domain at the C-terminal end. The middle region of human …

[PDF][PDF] Клинико-генетическое разнообразие и молекулярная диагностика мышечной дистрофии Эмери–Дрейфуса

ТА Адян - 2015 - med-gen.ru
Мышечная дистрофия Эмери–Дрейфуса (МД ЭД)–генетически гетерогенная группа
болезней, характеризующихся триадой типичных симптомов: первичными …