Abstract Since over 50 years, 5-fluorouracil (5-FU) is in use as backbone of chemotherapy
treatment regimens for a wide range of cancers including colon, breast, and head and neck …

The literature on inducers in epilepsy and bipolar disorder is seriously contaminated by false
negative findings. Part II of this comprehensive review on antiepileptic drug (AED) inducers …

Objective: The ABCB1 gene encodes P-glycoprotein, which limits brain concentrations of
certain antidepressants. ABCB1 variation has been associated with antidepressant efficacy …

The antimicrotubular agent docetaxel is a widely used chemotherapeutic drug for the
treatment of multiple solid tumors and is predominantly dependent on hepatic disposition. In …

Purpose To investigate the influence of ABCB1 polymorphisms on prognostic outcomes in
Chinese patients with de novo intermediate-risk acute myeloid leukemia (AML) and to …

Extrarenal adverse effects (AEs) associated with calcineurin inhibitor (CNI) and
mycophenolic acid (MPA) occur frequently but are unpredictable posttransplant …

Introduction Chemotherapy is the standard and recommended treatment for lung cancer
apart from surgery and radiotherapy. Chemotherapy is administered as mono-agents or as …

The potential for an interaction between lapatinib and absorption of the P‐glycoprotein
(ABCB1) substrate digoxin at a therapeutic dose in breast cancer patients was …

La literatura sobre los inductores en la epilepsia y el trastorno bipolar está contaminada por
falsos negativos. Esta segunda parte de una revisión exhaustiva sobre los fármacos …

Physiologically-based pharmacokinetic (PBPK) modelling is traditionally employed to
predict drug concentration-time profiles in plasma and tissues using information from …