Antimicrobial Resistance and Reduced Susceptibility in Clostridium difficile: Potential Consequences for Induction, Treatment, and Recurrence of C. difficile Infection

SD Baines, MH Wilcox - Antibiotics, 2015 - mdpi.com
Clostridium difficile infection (CDI) remains a substantial burden on healthcare systems and
is likely to remain so given our reliance on antimicrobial therapies to treat bacterial …

[HTML][HTML] Pan-European longitudinal surveillance of antibiotic resistance among prevalent Clostridium difficile ribotypes

J Freeman, J Vernon, K Morris, S Nicholson… - Clinical Microbiology …, 2015 - Elsevier
Clostridium difficile infection remains a major healthcare burden. Until the recent
introduction of fidaxomicin, antimicrobial treatments were limited to metronidazole and …

Simple faecal preparation and efficacy of frozen inoculum in faecal microbiota transplantation for recurrent Clostridium difficile infection – an observational cohort …

R Satokari, E Mattila, V Kainulainen… - Alimentary …, 2015 - Wiley Online Library
Background Faecal microbiota transplantation (FMT) is an effective treatment for recurrent
Clostridium difficile infection (rCDI). The finding of suitable donor, donor screening and …

Fidaxomicin-the new drug for Clostridium difficile infection

C Vaishnavi - Indian Journal of Medical Research, 2015 - journals.lww.com
Clostridium difficile is one of the many aetiological agents of antibiotic associated diarrhoea
and is implicated in 15-25 per cent of the cases. The organism is also involved in the …

Hospital-based Clostridium difficile infection surveillance reveals high proportions of PCR ribotypes 027 and 176 in different areas of Poland, 2011 to 2013

H Pituch, P Obuch-Woszczatyński… - …, 2015 - eurosurveillance.org
As part of the European Clostridium difficile infections (CDI) surveillance Network (ECDIS-
Net), which aims to build capacity for CDI surveillance in Europe, we constructed a new …

Mechanisms of hypervirulent Clostridium difficile ribotype 027 displacement of endemic strains: an epidemiological model

L Yakob, TV Riley, DL Paterson, J Marquess… - Scientific reports, 2015 - nature.com
Following rapid, global clonal dominance of hypervirulent ribotypes, Clostridium difficile now
constitutes the primary infectious cause of nosocomial diarrhoea. Evidence indicates at least …

Clostridium difficile PCR ribotype 018, a successful epidemic genotype

R Baldan, A Trovato, V Bianchini… - Journal of clinical …, 2015 - Am Soc Microbiol
Clostridium difficile infection (CDI) became a public health problem for the global spreading
of the so-called hypervirulent PCR ribotypes (RTs) 027 and 078, associated with increases …

Epidemiology of Clostridium difficile in Germany based on a single center long-term surveillance and German-wide genotyping of recent isolates provided to the …

L von Müller, M Mock, A Halfmann, J Stahlmann… - International Journal of …, 2015 - Elsevier
Epidemiology of Clostridium difficile is characterized by worldwide increase of C. difficile
infections (CDI) and the emergence of new epidemic outbreak strains with the capacity for …

Diagnosis of Clostridium difficile: real-time PCR detection of toxin genes in faecal samples is more sensitive compared to toxigenic culture

MBF Jensen, KEP Olsen, XC Nielsen… - European journal of …, 2015 - Springer
The diagnosis of Clostridium difficile infection (CDI) requires the detection of toxigenic C.
difficile or its toxins and a clinical assessment. We evaluated the performance of four nucleic …

Molecular characterization of nosocomial Clostridium difficile infection in pediatric ward in Iran

A Khoshdel, R Habibian, N Parvin, A Doosti, F Famouri… - Springerplus, 2015 - Springer
Clostridium difficile is recognized as a major cause of nosocomial acquired antibiotic-
associated diarrhea and pseudomembranous colitis. It is a significant financial burden on …