Structure, dynamics, assembly, and evolution of protein complexes
JA Marsh, SA Teichmann - Annual review of biochemistry, 2015 - annualreviews.org
The assembly of individual proteins into functional complexes is fundamental to nearly all
biological processes. In recent decades, many thousands of homomeric and heteromeric …
biological processes. In recent decades, many thousands of homomeric and heteromeric …
Fundamentals of protein interaction network mapping
Studying protein interaction networks of all proteins in an organism (“interactomes”) remains
one of the major challenges in modern biomedicine. Such information is crucial to …
one of the major challenges in modern biomedicine. Such information is crucial to …
The Symbiodinium kawagutii genome illuminates dinoflagellate gene expression and coral symbiosis
Dinoflagellates are important components of marine ecosystems and essential coral
symbionts, yet little is known about their genomes. We report here on the analysis of a high …
symbionts, yet little is known about their genomes. We report here on the analysis of a high …
[HTML][HTML] Meta-research: evaluation and improvement of research methods and practices
As the scientific enterprise has grown in size and diversity, we need empirical evidence on
the research process to test and apply interventions that make it more efficient and its results …
the research process to test and apply interventions that make it more efficient and its results …
Comparing the performance of biomedical clustering methods
C Wiwie, J Baumbach, R Röttger - Nature methods, 2015 - nature.com
Identifying groups of similar objects is a popular first step in biomedical data analysis, but it
is error-prone and impossible to perform manually. Many computational methods have been …
is error-prone and impossible to perform manually. Many computational methods have been …
The k-clique densest subgraph problem
C Tsourakakis - Proceedings of the 24th international conference on …, 2015 - dl.acm.org
Numerous graph mining applications rely on detecting subgraphs which are large near-
cliques. Since formulations that are geared towards finding large near-cliques are hard and …
cliques. Since formulations that are geared towards finding large near-cliques are hard and …
Promises and challenges of big data computing in health sciences
With the development of smart devices and cloud computing, more and more public health
data can be collected from various sources and can be analyzed in an unprecedented way …
data can be collected from various sources and can be analyzed in an unprecedented way …
[HTML][HTML] The ocean sampling day consortium
A Kopf, M Bicak, R Kottmann, J Schnetzer, I Kostadinov… - Gigascience, 2015 - Springer
Abstract Ocean Sampling Day was initiated by the EU-funded Micro B3 (Marine Microbial
Biodiversity, Bioinformatics, Biotechnology) project to obtain a snapshot of the marine …
Biodiversity, Bioinformatics, Biotechnology) project to obtain a snapshot of the marine …
Systematic identification of arsenic-binding proteins reveals that hexokinase-2 is inhibited by arsenic
H Zhang, L Yang, J Ling… - Proceedings of the …, 2015 - National Acad Sciences
Arsenic is highly effective for treating acute promyelocytic leukemia (APL) and has shown
significant promise against many other tumors. However, although its mechanistic effects in …
significant promise against many other tumors. However, although its mechanistic effects in …
Big data analytics in bioinformatics: A machine learning perspective
Bioinformatics research is characterized by voluminous and incremental datasets and
complex data analytics methods. The machine learning methods used in bioinformatics are …
complex data analytics methods. The machine learning methods used in bioinformatics are …