Ageing is the main risk factor for major non-communicable chronic lung diseases, including
chronic obstructive pulmonary disease, most forms of lung cancer and idiopathic pulmonary …

Advances in physiology and biochemistry have provided fundamental insights into the role
of pulmonary surfactant in the pathogenesis and treatment of preterm infants with respiratory …

Idiopathic pulmonary fibrosis (IPF) is an age-related disease featuring progressive lung
scarring. To elucidate the molecular basis of IPF, we performed exome sequencing of …

Throughout the past decade, there have been substantial advances in understanding the
pathogenesis of idiopathic pulmonary fibrosis (IPF). Recently, several large genome-wide …

Rationale: Up to 20% of cases of idiopathic interstitial pneumonia cluster in families,
comprising the syndrome of familial interstitial pneumonia (FIP); however, the genetic basis …

The current usual interstitial pneumonitis (UIP)/idiopathic pulmonary fibrosis CT scan
classification system excludes probable UIP as a diagnostic category. We sought to …

Rationale: Asymptomatic relatives of patients with familial interstitial pneumonia (FIP), the
inherited form of idiopathic interstitial pneumonia, carry increased risk for developing …

Idiopathic pulmonary fibrosis (IPF) is a complex lung disease of unknown etiology.
Development of IPF is influenced by both genetic and environmental factors. Recent work by …

Idiopathic pulmonary fibrosis (IPF) is the most common and lethal form of idiopathic
interstitial pneumonia. The disease, which occurs primarily in middle-aged and older adults …

Dating back nearly 35 years ago to the Witschi hypothesis, epithelial cell dysfunction and
abnormal wound healing have reemerged as central concepts in the pathophysiology of …