Nonsense-mediated mRNA decay: degradation of defective transcripts is only part of the story
F He, A Jacobson - Annual review of genetics, 2015 - annualreviews.org
Nonsense-mediated mRNA decay (NMD) is a eukaryotic surveillance mechanism that
monitors cytoplasmic mRNA translation and targets mRNAs undergoing premature …
monitors cytoplasmic mRNA translation and targets mRNAs undergoing premature …
Unique aspects of plant nonsense-mediated mRNA decay
O Shaul - Trends in plant science, 2015 - cell.com
Nonsense-mediated mRNA Decay (NMD) is a eukaryotic quality-control mechanism that
governs the stability of both aberrant and normal transcripts. Although plant and mammalian …
governs the stability of both aberrant and normal transcripts. Although plant and mammalian …
Mechanism, factors, and physiological role of nonsense-mediated mRNA decay
T Fatscher, V Boehm, NH Gehring - Cellular and Molecular Life Sciences, 2015 - Springer
Nonsense-mediated mRNA decay (NMD) is a translation-dependent, multistep process that
degrades irregular or faulty messenger RNAs (mRNAs). NMD mainly targets mRNAs with a …
degrades irregular or faulty messenger RNAs (mRNAs). NMD mainly targets mRNAs with a …
Full UPF3B function is critical for neuronal differentiation of neural stem cells
T Alrahbeni, F Sartor, J Anderson, Z Miedzybrodzka… - Molecular brain, 2015 - Springer
Background Mutation in the UPF3B gene on chromosome X is implicated in
neurodevelopmental disorders including X-linked intellectual disability, autism and …
neurodevelopmental disorders including X-linked intellectual disability, autism and …
HIV-1 recruits UPF1 but excludes UPF2 to promote nucleocytoplasmic export of the genomic RNA
Unspliced, genomic HIV-1 RNA (vRNA) is a component of several ribonucleoprotein
complexes (RNP) during the viral replication cycle. In earlier work, we demonstrated that the …
complexes (RNP) during the viral replication cycle. In earlier work, we demonstrated that the …
[HTML][HTML] mRNA metabolism and neuronal disease
To serve as templates for translation eukaryotic mRNAs undergo an elaborate processing
and maturation pathway. In eukaryotes this process comprises the synthesis of mRNA …
and maturation pathway. In eukaryotes this process comprises the synthesis of mRNA …
The feedback control of UPF3 is crucial for RNA surveillance in plants
E Degtiar, A Fridman, D Gottlieb, K Vexler… - Nucleic acids …, 2015 - academic.oup.com
Abstract Nonsense-mediated-decay (NMD) is a eukaryotic RNA surveillance mechanism
that controls the levels of both aberrant and normal transcripts. The regulation of this process …
that controls the levels of both aberrant and normal transcripts. The regulation of this process …
[PDF][PDF] Autism and Non Sense Mediated Decay (NMD)
A Autism - pdfs.semanticscholar.org
AUTISM Autism is a complex childhood developmental disability that causes problems with
social interaction and communication [1, 2].“Infantile Autism” was first diagnosed and …
social interaction and communication [1, 2].“Infantile Autism” was first diagnosed and …
Surveillance of mRNP composition during translation termination regulates gene expression via nonsense-mediated mRNA decay
V Böhm - 2015 - kups.ub.uni-koeln.de
Eukaryotic gene expression consists of a series of events mediating the information flow
from DNA via mRNA to protein. Cellular surveillance mechanisms exist to detect and …
from DNA via mRNA to protein. Cellular surveillance mechanisms exist to detect and …
Study of molecules with nonsense mutation correction capacity
J Jia - 2015 - theses.hal.science
Nonsense mutations represent approximately 10% of mutations found in the inherited
geneticdiseases. mRNAs harboring a nonsense mutation are rapidly degraded by a quality …
geneticdiseases. mRNAs harboring a nonsense mutation are rapidly degraded by a quality …