Puberty presents remarkable individual differences in timing reaching over 5 years in
humans. We put emphasis on the two edges of the age distribution of pubertal signs in …

Follicle-stimulating hormone (FSH) plays fundamental roles in male and female fertility. FSH
is a heterodimeric glycoprotein expressed by gonadotrophs in the anterior pituitary. The …

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic
outcomes, independent of overall adiposity. To increase our understanding of the genetic …

Males and females share many traits that have a common genetic basis; however, selection
on these traits often differs between the sexes, leading to sexual conflict,. Under such sexual …

Obesity is heritable and predisposes to many diseases. To understand the genetic basis of
obesity better, here we conduct a genome-wide association study and Metabochip meta …

Understanding of the genetic regulation of puberty timing has come largely from studies of
rare disorders and population-based studies in women. Here, we report the largest genomic …

Substantial research has implicated the hypothalamic‐pituitary‐adrenal (HPA) and
hypothalamic‐pituitary‐gonadal (HPG) axes independently in adolescent mental health …

Context: Delayed puberty (DP) is a common issue and, in the absence of an underlying
condition, is typically self limited. Alhough DP seems to be heritable, no specific genetic …

Context: Puberty is initiated by a complex interaction of suppressing and stimulating factors.
Genetic studies of familial central precocious puberty have suggested makorin ring finger …

In primates, puberty is unleashed by increased GnRH release from the hypothalamus
following an interval of juvenile quiescence. GWAS implicates Zinc finger (ZNF) genes in …