Staphylococcus aureus infections: epidemiology, pathophysiology, clinical manifestations, and management

SYC Tong, JS Davis, E Eichenberger… - Clinical microbiology …, 2015 - Am Soc Microbiol
Staphylococcus aureus is a major human pathogen that causes a wide range of clinical
infections. It is a leading cause of bacteremia and infective endocarditis as well as …

2015 infectious diseases society of America (IDSA) clinical practice guidelines for the diagnosis and treatment of native vertebral osteomyelitis in adultsa

EF Berbari, SS Kanj, TJ Kowalski… - Clinical infectious …, 2015 - doc.rero.ch
These guidelines are intended for use by infectious disease specialists, orthopedic
surgeons, neurosurgeons, radiologists, and other healthcare professionals who care for …

[HTML][HTML] ESCMID guideline for the diagnosis and treatment of biofilm infections 2014

N Høiby, T Bjarnsholt, C Moser, GL Bassi… - Clinical microbiology …, 2015 - Elsevier
Biofilms cause chronic infections in tissues or by developing on the surfaces of medical
devices. Biofilm infections persist despite both antibiotic therapy and the innate and adaptive …

Biomimetic approaches in bone tissue engineering: Integrating biological and physicomechanical strategies

MA Fernandez-Yague, SA Abbah, L McNamara… - Advanced drug delivery …, 2015 - Elsevier
The development of responsive biomaterials capable of demonstrating modulated function
in response to dynamic physiological and mechanical changes in vivo remains an important …

The role of microbial biofilms in prosthetic joint infections: A review

HO Gbejuade, AM Lovering, JC Webb - Acta orthopaedica, 2015 - Taylor & Francis
Prosthetic joint infection (PJI) still remains a significant problem. In line with the forecasted
rise in joint replacement procedures, the number of cases of PJI is also anticipated to rise …

Current failure mechanisms after knee arthroplasty have changed: polyethylene wear is less common in revision surgery

K Thiele, C Perka, G Matziolis, HO Mayr, M Sostheim… - JBJS, 2015 - journals.lww.com
Background: The present study was designed to clarify which underlying indications can be
currently considered the main reasons for failure after total knee arthroplasty as a function of …

Quantifying the natural history of biofilm formation in vivo during the establishment of chronic implant‐associated Staphylococcus aureus osteomyelitis in mice to …

K Nishitani, W Sutipornpalangkul… - Journal of …, 2015 - Wiley Online Library
While it is well known that Staphylococcus aureus establishes chronic implant‐associated
osteomyelitis by generating and persisting in biofilm, research to elucidate pathogen, and …

The “true” incidence of surgically treated deep prosthetic joint infection after 32,896 primary total hip arthroplasties: a prospective cohort study

PH Gundtoft, S Overgaard, HC Schønheyder… - Acta …, 2015 - Taylor & Francis
Background and purpose—It has been suggested that the risk of prosthetic joint infection
(PJI) in patients with total hip arthroplasty (THA) may be underestimated if based only on …

Improved diagnosis of orthopedic implant-associated infection by inoculation of sonication fluid into blood culture bottles

ME Portillo, M Salvadó, A Trampuz… - Journal of clinical …, 2015 - Am Soc Microbiol
Sonication improved the diagnosis of orthopedic implant-associated infections (OIAI). We
investigated the diagnostic performance of sonication fluid inoculated into blood culture …

Circulating biomarkers for discrimination between aseptic joint failure, low-grade infection, and high-grade septic failure

M Ettinger, T Calliess, JT Kielstein… - Clinical Infectious …, 2015 - academic.oup.com
Background. Late-onset chronic (low-grade) periprosthetic joint infections are often
accompanied by unspecific symptoms, false-negative cultures or nonspecific low values of …