Advances in the depth and quality of transcriptome sequencing have revealed many new
classes of long noncoding RNAs (lncRNAs). lncRNA classification has mushroomed to …

The human body contains several hundred cell types, all of which share the same genome.
In metazoans, much of the regulatory code that drives cell type-specific gene expression is …

Diverse classes of RNA, ranging from small to long non-coding RNAs, have emerged as key
regulators of gene expression, genome stability and defence against foreign genetic …

Neuronal activity causes the rapid expression of immediate early genes that are crucial for
experience-driven changes to synapses, learning, and memory. Here, using both molecular …

Neuronal diversity is essential for mammalian brain function but poses a challenge to
molecular profiling. To address the need for tools that facilitate cell-type-specific epigenomic …

In recent year, increasing evidence suggests that noncoding RNAs play important roles in
the regulation of tissue homeostasis and pathophysiological conditions. Besides small …

The mammalian radiation has corresponded with rapid changes in noncoding regions of the
genome, but we lack a comprehensive understanding of regulatory evolution in mammals …

Transcription factors (TFs) bind specific sequences in promoter-proximal and-distal DNA
elements to regulate gene transcription. RNA is transcribed from both of these DNA …

Alzheimer's disease (AD) is a severe age-related neurodegenerative disorder characterized
by accumulation of amyloid-β plaques and neurofibrillary tangles, synaptic and neuronal …

Disruption of the MECP2 gene leads to Rett syndrome (RTT), a severe neurological disorder
with features of autism. MECP2 encodes a methyl-DNA-binding protein that has been …