Significance: Inflammasomes are multiprotein complexes localized within the cytoplasm of
the cell that are responsible for the maturation of proinflammatory cytokines such as …

Research studying the role of inflammation in hypertension and cardiovascular disease has
flourished in recent years; however, the exact mechanisms by which the activated immune …

Autoantibodies to components of apoptotic cells, such as anti-perlecan antibodies,
contribute to rejection in organ transplant recipients. However, mechanisms of immunization …

IL-1β-secreting nucleotide-binding oligomerization domain protein 3 (NLRP3)
inflammasomes play a pivotal role in triggering innate immune responses in metabolic …

Albuminuria contributes to the development and progression of chronic kidney disease by
inducing tubulointerstitial inflammation (TI) and fibrosis. However, the exact mechanisms of …

The mononuclear phagocytes (dendritic cells and macrophages) are closely related immune
cells with central roles in anti-infectious defense and maintenance of organ integrity. The …

ABSTRACT The NACHT, LRR, and PYD domains‐containing protein 3 (NLRP3)
inflammasome plays an important role in a variety of diseases. However, the role of NLRP3 …

To assess whether NLR pyrin domain-containing protein 3 (NLRP3) inflammasome, a
multiprotein complex that mediates the activation of caspase-1 (CASP-1) and pro …

Proteinuria is involved in the development of tubular lesions and in the progressive loss of
renal function in chronic kidney diseases via uncertain mechanisms. Growing evidence …

Diabetic nephropathy (DN) is one of the major causes of end‐stage renal disease, and
previously we demonstrated that NALP3 inflammasome was involved in the pathogenesis of …