Effects of increased paternal age on sperm quality, reproductive outcome and associated epigenetic risks to offspring

R Sharma, A Agarwal, VK Rohra, M Assidi… - Reproductive Biology …, 2015 - Springer
Over the last decade, there has been a significant increase in average paternal age when
the first child is conceived, either due to increased life expectancy, widespread use of …

Human sperm chromatin epigenetic potential: genomics, proteomics, and male infertility

J Castillo, JM Estanyol, JL Ballescà… - Asian Journal of …, 2015 - journals.lww.com
The classical idea about the function of the mammalian sperm chromatin is that it serves to
transmit a highly protected and transcriptionally inactive paternal genome, largely …

Post‐translational modifications of histones in human sperm

J Krejčí, L Stixová, E Pagáčová… - Journal of cellular …, 2015 - Wiley Online Library
We examined the levels and distribution of post‐translationally modified histones and
protamines in human sperm. Using western blot immunoassay, immunofluorescence, mass …

Epigenetic alterations in density selected human spermatozoa for assisted reproduction

B Yu, H Zhou, M Liu, T Zheng, L Jiang, M Zhao, X Xu… - PLoS …, 2015 - journals.plos.org
Epidemiological evidence indicates that assisted reproductive technologies (ART) may be
associated with several epigenetic diseases such as Beckwith-Wiedemann syndrome …

Impact of sperm genome decay on Day‐3 embryo chromosomal abnormalities from advanced‐maternal‐age patients

I Kaarouch, N Bouamoud, N Louanjli… - Molecular …, 2015 - Wiley Online Library
Infertile male patients often exhibit unconventional semen parameters, including DNA
fragmentation, chromatin dispersion, and aneuploidy—collectively referred to as sperm …

Genetic Basis of Unexplained Male Infertility

R Miyaoka, SC Esteves - Unexplained Infertility: Pathophysiology …, 2015 - Springer
Approximately 12% of the subfertile males attending our tertiary center for male
reproduction, in which all male partners undergo andrological examination regardless of …