Cerebrospinal fluid VILIP-1 and YKL-40, candidate biomarkers to diagnose, predict and monitor Alzheimer's disease in a memory clinic cohort

MI Kester, CE Teunissen, C Sutphen… - Alzheimer's research & …, 2015 - Springer
Introduction We examined the utility of cerebrospinal fluid (CSF) proteins, Chitinase-3-like
protein 1 (CHI3L1 or YKL-40), a putative marker of inflammation, and Visinin-like protein-1 …

Informants' perception of subjective cognitive decline helps to discriminate preclinical Alzheimer's disease from normal aging

N Valech, MA Mollica, J Olives, A Tort… - Journal of …, 2015 - content.iospress.com
Background: Self-reported and informant-reported subjective cognitive decline (SCD) may
be useful in the detection of preclinical Alzheimer's disease (Pre-AD) and cognitive …

[HTML][HTML] Longitudinal cerebrospinal fluid biomarker measurements in preclinical sporadic Alzheimer's disease: A prospective 9-year study

E Stomrud, L Minthon, H Zetterberg, K Blennow… - Alzheimer's & Dementia …, 2015 - Elsevier
Introduction Ascertainment of the pattern and temporal change of biomarkers in preclinical
(asymptomatic) sporadic Alzheimer's disease (AD) will increase knowledge about early …

Concordance and diagnostic accuracy of [11C] PIB PET and cerebrospinal fluid biomarkers in a sample of patients with mild cognitive impairment and Alzheimer's …

A Leuzy, SF Carter, K Chiotis… - Journal of …, 2015 - content.iospress.com
Background: Alzheimer's disease (AD) pathology can be quantified in vivo using
cerebrospinal fluid (CSF) levels of amyloid-1-42 (A1-42), total-tau (t-tau), and …

Homozygous carriers of APP A713T mutation in an autosomal dominant Alzheimer disease family

ME Conidi, L Bernardi, G Puccio, N Smirne… - Neurology, 2015 - AAN Enterprises
Objective: To report, for the first time, a large autosomal dominant Alzheimer disease (AD)
family in which the APP A713T mutation is present in the homozygous and heterozygous …

Boosting brain connectome classification accuracy in Alzheimer's disease using higher-order singular value decomposition

L Zhan, Y Liu, Y Wang, J Zhou, N Jahanshad… - Frontiers in …, 2015 - frontiersin.org
Alzheimer's disease (AD) is a progressive brain disease. Accurate detection of AD and its
prodromal stage, mild cognitive impairment (MCI), are crucial. There is also a growing …

Indole and indoline derivatives and methods of use thereof

MR Schrimpf, CH Lee, T Li, GA Gfesser… - US Patent …, 2015 - Google Patents
2009-10-05 Assigned to ABBOTT LABORATORIES reassignment ABBOTT LABORATORIES
ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors …

[PDF][PDF] Imaging patterns of tissue destruction. Towards a better discrimination between types of dementia

C Moller - 2015 - research.vumc.nl
Objectives: Validate the four-point visual rating scale for posterior cortical atrophy (PCA) on
magnetic resonance images (MRI) through quantitative grey matter (GM) volumetry and …

Benzodiazepine and pyridodiazepine derivatives

WH Bunnelle, M Scanio, JT Brewer, Y Wang… - US Patent …, 2015 - Google Patents
US9133206B2 - Benzodiazepine and pyridodiazepine derivatives - Google Patents
US9133206B2 - Benzodiazepine and pyridodiazepine derivatives - Google Patents …