Unique dysregulated expression patterns of microRNAs (miRNAs) have been reported in
many disease conditions including autoimmune diseases such as systemic lupus …

Treat-to-target is a therapeutic strategy aimed at improving disease outcome through the
achievement of shared treatment goals, which has dramatically ameliorated the prognosis of …

Background Systemic lupus erythematosus (SLE) is an autoimmune disease with a high
degree of variability at onset that is problematic for a correct and prompt diagnosis. We …

Objective. The aim of this study was to develop an SLE disease model that simulates long-
term outcomes of SLE to estimate the long-term effectiveness and cost-effectiveness of SLE …

Background Eltrombopag activates the thrombopoietin (TPO) surface receptor on the
megakaryocyte, which increases the production of platelets, and rapidly improves circulating …

The management of systemic lupus erythematosus (SLE) is complicated by heterogeneous
clinical presentations, a lack of universally accepted tools for the measurement of disease …

Belimumab (Benlysta®) is a fully humanized monoclonal antibody that inhibits B-lymphocyte
stimulator (also known as B cell activating factor of the tumor necrosis factor family) and was …

Background. The antiphospholipid syndrome (APS) is one of the most encountered
autoimmunity in systemic lupus erythematosus (SLE) patients and pathogenesis of these …

Implementing a 'treat-to-target'(T2T) strategy that aims to improve disease outcomes through
achievement of prespecified treatment goals has proven efficacy in chronic medical …

Цель исследования—изучение частоты необратимых изменений со стороны органов и
систем уподростков, больных системной крас-ной волчанкой, путем определения уних …