Feasibility studies are increasingly undertaken in preparation for randomised controlled
trials in order to explore uncertainties and enable trialists to optimise the intervention or the …

Purpose To outline some of the challenges of mixed methods research and illustrate how
they can be addressed in health psychology research. Methods This study critically reflects …

Background Atypical meningiomas are an intermediate grade brain tumour with a
recurrence rate of 39–58%. It is not known whether early adjuvant radiotherapy reduces the …

Background: After the decades of the so-called 'paradigm wars' in social science research
methodology and the controversy about the relative place and value of quantitative and …

Background In the UK, the recruitment of patients into clinical research is a national health
research and development policy priority. There has been limited investigation of how …

Background Acellular dermal matrix (ADM) may improve outcomes in implant-based breast
reconstruction (IBBR). The aim of this study was critically to appraise and evaluate the …

Objective To determine whether intensive combinations of synthetic disease modifying
drugs can achieve similar clinical benefits at lower costs to high cost biologics such as …

Background The hundreds of thousands of patients found to have a potentially malignant
pulmonary nodule each year are faced with tremendous uncertainty regarding what the …

Background Conservative kidney management (CKM) is recognised as an alternative to
dialysis for a significant number of older adults with multimorbid stage 5 chronic kidney …

Background: Recruitment difficulties are a well-reported concern in surgical literature, which
may be improved by patient and public involvement (PPI). PPI within research has been …