Understanding the pathogenesis of abdominal aortic aneurysms

H Kuivaniemi, EJ Ryer, JR Elmore… - Expert review of …, 2015 - Taylor & Francis
An aortic aneurysm is a dilatation in which the aortic diameter is≥ 3.0 cm. If left untreated,
the aortic wall continues to weaken and becomes unable to withstand the forces of the …

Abdominal aortic aneurysm: novel mechanisms and therapies

FM Davis, DL Rateri, A Daugherty - Current opinion in cardiology, 2015 - journals.lww.com
Abdominal aortic aneurysm: novel mechanisms and therapies : Current Opinion in
Cardiology Abdominal aortic aneurysm: novel mechanisms and therapies : Current Opinion …

Segmental aortic stiffening contributes to experimental abdominal aortic aneurysm development

U Raaz, AM Zöllner, IN Schellinger, R Toh… - Circulation, 2015 - Am Heart Assoc
Background—Stiffening of the aortic wall is a phenomenon consistently observed in age and
in abdominal aortic aneurysm (AAA). However, its role in AAA pathophysiology is largely …

Local microRNA modulation using a novel anti-miR-21–eluting stent effectively prevents experimental in-stent restenosis

D Wang, T Deuse, M Stubbendorff… - … , and vascular biology, 2015 - Am Heart Assoc
Objective—Despite advances in stent technology for vascular interventions, in-stent
restenosis (ISR) because of myointimal hyperplasia remains a major complication …

Chaperone Hsp47 drives malignant growth and invasion by modulating an ECM gene network

J Zhu, G Xiong, H Fu, BM Evers, BP Zhou, R Xu - Cancer research, 2015 - AACR
The extracellular matrix (ECM) is a determining factor in the tumor microenvironment that
restrains or promotes malignant growth. In this report, we show how the molecular …

The two faces of miR-29

A Slusarz, L Pulakat - Journal of cardiovascular medicine, 2015 - journals.lww.com
Diabetes mellitus is a metabolic homeostasis disease that contributes to additional
comorbidities such as cardiovascular disease (CVD) and cancer. It has a long undiagnosed …

microRNAs in cerebrovascular disease

O Volný, L Kašičková, D Coufalová, P Cimflová… - … Medical Evidence: From …, 2015 - Springer
Cardiovascular diseases are major causes of morbidity and mortality in developed
countries. Cerebrovascular diseases, especially stroke, represent major burden of disability …

Identification of microRNAs associated with abdominal aortic aneurysms and peripheral arterial disease

PW Stather, N Sylvius, DA Sidloff… - Journal of British …, 2015 - academic.oup.com
Background MicroRNAs are crucial in the regulation of cardiovascular disease and
represent potential therapeutic targets to decrease abdominal aortic aneurysm (AAA) …

Plasma microRNAs serve as potential biomarkers for abdominal aortic aneurysm

W Zhang, T Shang, C Huang, T Yu, C Liu, T Qiao… - Clinical …, 2015 - Elsevier
Objectives Abdominal aortic aneurysm (AAA) is often asymptomatic until rupture occurs.
Although ultrasound screening has significantly improved the early diagnosis of AAA, the …

Regulatory T cells in human and angiotensin II-induced mouse abdominal aortic aneurysms

Y Zhou, W Wu, JS Lindholt, GK Sukhova… - Cardiovascular …, 2015 - academic.oup.com
Abstract Aims Regulatory T cells (Tregs) protect mice from angiotensin II (Ang-II)-induced
abdominal aortic aneurysms (AAA). This study tested whether AAA patients are Treg …