Inflammasome biology is one of the most exciting and rapidly growing areas in immunology.
Over the past 10 years, inflammasomes have been recognized for their roles in the host …

Our understanding of the genetic basis of systemic lupus erythematosus has progressed
rapidly in recent years. While many genetic polymorphisms have been associated with …

Background: Epigenome-wide association scans (EWAS) are under way for many complex
human traits, but EWAS power has not been fully assessed. We investigate power of EWAS …

Aicardi–Goutières syndrome (AGS) is a severe childhood inflammatory disorder that shows
clinical and genetic overlap with systemic lupus erythematosus (SLE). AGS is thought to …

Introduction DNA methylation is an epigenetic mechanism regulating gene expression that
has been insufficiently studied in the blood of rheumatoid arthritis (RA) patients, as only T …

Epigenetics is the study of heritable changes in genome function without underlying
modifications in their nucleotide sequence. Disorders of epigenetic processes, which involve …

Since the final decades of the last century, twin studies have made a remarkable
contribution to the genetics of human complex traits and diseases. With the recent rapid …

Epigenetic modifications, such as histone post-translational modifications, DNA methylation,
and alteration of gene expression by non-coding RNAs, including microRNAs (miRNAs) and …

Clustered regularly interspaced palindromic repeats (CRISPR)-associated (Cas9)
technology has proven a formidable addition to our armory of approaches for genomic …

Objective Systemic lupus erythematosus (SLE) is a complex autoimmune disease
characterised by heterogeneous clinical manifestations, autoantibody production and …