Cardiac muscle cells have an intrinsic ability to sense and respond to mechanical load
through a process known as mechanotransduction. In the heart, this process involves the …

The fetal circulation is an entirely transient event, not replicated at any point in later life, and
functionally distinct from the pediatric and adult circulations. Understanding of the …

Background—The purpose of this study was to determine whether patients with heart failure
and a preserved ejection fraction (HFpEF) have an increase in passive myocardial stiffness …

Truncating mutations in the giant sarcomeric protein Titin result in dilated cardiomyopathy
and skeletal myopathy. The most severely affected dilated cardiomyopathy patients harbor …

Objective Ventricular kinetic energy measurements may provide a novel imaging biomarker
of declining ventricular efficiency in patients with repaired tetralogy of Fallot. Our purpose …

Aims Accumulating evidence suggest that sarcomere signalling complexes play a pivotal
role in cardiomyocyte hypertrophy by communicating stress signals to the nucleus to induce …

Cardiomyocytes derived from human stem cells are quickly becoming mainstays of cardiac
regenerative medicine, in vitro disease modeling, and drug screening. Their suitability for …

New Findings What is the topic of this review? At high altitude, the cardiovascular system
must adapt in order to meet the metabolic demand for oxygen. This review summarizes …

Although mammals are thought to lose their capacity to regenerate heart muscle shortly after
birth, embryonic and neonatal cardiomyocytes in mammals are hyperplastic. During …

Epigenetic mechanisms are fundamental in cardiac adaptations, remodeling, reverse
remodeling, and disease. A primary goal of translational cardiovascular research is …