Epigenetics studies the emergence of different phenotypes from a single genotype. Although
these processes are essential to cellular differentiation and transcriptional memory, they are …

We have previously described novel histone acetyltransferase (HAT) inhibitors that block
neuroblastoma cell growth in vitro. Here we show that two selected pyridoisothiazolone HAT …

We described herein structure-based design, synthesis and evaluation of conformationally
constrained, cyclic peptidomimetics to block the MLL1-WDR5 protein–protein interaction as …

During the last decade, our understanding of the molecular mechanisms regulating the
cellular environment has made significant advances. With the new dynamical description of …

SWI/SNF is a chromatin-remodeling complex and Brahma (BRM) is the ATPase subunit of
SWI/SNF. BRM regulates transcription by remodeling the nucleosomes at promoter regions …

My dissertation work can be separated into two major research areas. The first focuses on a
type of nucleic acid structures called R-loops. An R-loop is a three-stranded structure …