Nephrin is a key molecule in podocytes to maintain normal slit diaphragm structure. Nephin
interacts with many other podocyte and slit diaphragm protein and also mediates important …

The Wilms' tumor suppressor gene 1 (WT1) encodes a zinc finger transcription factor.
Mutation of WT1 in humans leads to Wilms' tumor, a pediatric kidney tumor, or other kidney …

Synaptic adhesion molecules regulate diverse aspects of neuronal synapse development,
including synapse specificity, formation, and maturation. Neph2, also known as Kirrel3, is an …

Most animal tissues and organ systems are comprised of highly ordered arrays of varying
cell types. The development of external sensory organs requires complex cell-cell …

Direct interactions among pancreatic β-cells via cell surface proteins inhibit basal and
enhance stimulated insulin secretion. Here, we functionally and biochemically characterized …

The coxsackie-and adenovirus receptor (CXADR) is a member of the immunoglobulin
protein superfamily, present in various epithelial cells including glomerular epithelial cells …

Receptor ROBO2 and its ligand SLIT2 are required for ureteric bud outgrowth during early
kidney development. However, it is unclear if ROBO2 also plays a role during the late stage …

Glomerular filtration is a vital physiological process removing waste products from the
circulation and this process occurs across the glomerular filtration barrier (GFB). The cells …

The ability of animals to detect signals from the environment is regulated by the sensory
systems. One of these sensory systems, the accessory olfactory system, controls various …

Thin-basement-membrane nephropathy (TBMN) and Alport syndrome (AS) are hereditary
collagen IV glomerulopathies caused by mutations in the COL4A3/A4/A5 genes. Clinical …