Arterial stiffening occurs with age and is closely associated with the progression of
cardiovascular disease. Stiffening is most often studied at the level of the whole vessel …

Inflammatory diseases of the aorta include routine atherosclerosis, aortitis, periaortitis, and
atherosclerosis with excessive inflammatory responses, such as inflammatory …

Characterisation and quantification of tissue structures is limited by sectioning-induced
artefacts and by the difficulties of visualising and segmenting 3D volumes. Here we …

As major extracellular matrix components, elastin, and collagen play crucial roles in
regulating the mechanical properties of the aortic wall and, thus, the normal cardiovascular …

Rationale: Aortic dissection or rupture resulting from aneurysm causes 1% to 2% of deaths
in developed countries. These disorders are associated with mutations in genes that affect …

Homozygous recessive mutations in either EFEMP2 (encoding fibulin-4) or FBLN5
(encoding fibulin-5), critical genes for elastogenesis, lead to autosomal recessive cutis laxa …

Although engineered blood vessels have seen important advances during recent years,
proper mechanical strength and vasoactivity remain unsolved problems. In the current study …

Bridging veins drain the venous blood from the cerebral cortex into the superior sagittal
sinus (SSS) and doing so they bridge the subdural space. Despite their importance in head …

Elastin is essential to provide elastic support for blood vessels. As a remarkably long-lived
protein, elastin can suffer from cumulative effects of exposure to biochemical damages …

Directional cell migration induced by the stiffness gradient of cell culture substrates is known
as a subset of the mechanical-cue-induced taxis, so-called mechanotaxis, typically durotaxis …