Optimal cardiac function depends on proper timing of excitation and contraction in various
regions of the heart, as well as on appropriate heart rate. This is accomplished via …

Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia, affecting 1% to 2% of the
general population. It is characterized by rapid and disorganized atrial activation leading to …

Atrial fibrillation (AF) is the most common sustained arrhythmia in clinical practice and a
major cause of morbidity and mortality. Although the fundamental mechanisms underlying …

Decades of cardiovascular research have shown that variable and flexible levels of protein
phosphorylation are necessary to maintain cardiac function. A delicate balance between …

Atrial fibrillation (AF) is a highly prevalent condition associated with pronounced
cardiovascular-related morbidity, mortality and socioeconomic burden. It accounts for more …

In the heart, the main pathway for calcium influx is mediated by L-type calcium channels, a
multi-subunit complex composed of the pore-forming subunit Ca V 1.2 and the auxiliary …

Atrial fibrillation (AF) is the most common cardiac arrhythmia in developed countries. AF is
associated with increased mortality and morbidity due to thromboembolism, stroke and …

心血管疾病是全球范围内首要的致死原因, 严重威胁人类的生命健康. 兰尼碱2 受体(RyR2)
是心肌细胞肌浆网上重要的钙释放通道, 其调控机制复杂, 一些相关研究仍存在争议. RyR2 …

Atrial fibrillation (AF) is the most common cardiac arrhythmia encountered in the clinical
practice. However, the underlying mechanism or pathophysiology is not fully understood …

Vorhofflimmern ist die häufigste anhaltende Herzrhythmusstörung, die mit dem Alter stetig in
der Prävalenz zunimmt. Bis zu 15% der 80-jährigen sind betroffen. Zudem ist die Mortalität …