Background Recently, the use of nanotechnology has been expanding very rapidly in
diverse areas of research, such as consumer products, energy, materials, and medicine …

Rocaglamides (= flavaglines) are potent natural anti‐cancer phytochemicals that inhibit
cancer growth at nanomolar concentrations by the following mechanisms:(1) inhibition of …

The pathological hallmarks of Alzheimer's disease (AD) include amyloid beta (Aβ)
accumulation, neurofibrillary tangle formation, synaptic dysfunction and neuronal loss. In this …

Background The p53 protein family, comprising p53, p63 and p73, is primarily involved in
preserving genome integrity and preventing tumor onset, and also affects a range of …

Astrocytes are critical for ischemic stroke, and understanding their role in mesenchymal stem
cell (MSC)‐mediated protection against ischemic injury is important. The paracrine capacity …

Although members of SOX family have been well documented for their essential roles in
embryonic development, cell proliferation and disease, the functional role and molecular …

Traumatic brain injury (TBI) is a major cause of death and disability worldwide. Programmed
death of neuronal cells plays a crucial role in acute and chronic neurodegeneration …

Cerebral ischemic injury involves death of multiple cell types at the ischemic sites. As a key
regulator of cell death, the p53 gene has been implicated in the regulation of cell loss in …

Pactamycin, although putatively touted as a potent antitumor agent, has never been used as
an anticancer drug due to its high cytotoxicity. In this study, we characterized the effects of …

Tumor suppressor p53 has recently been reported to have numerous functions independent
of tumorigenesis, including neuronal survival during ischemia. The mammalian target of …