mTOR in brain physiology and pathologies

J Bockaert, P Marin - Physiological reviews, 2015 - journals.physiology.org
TOR (target of rapamycin) and its mammalian ortholog mTOR have been discovered in an
effort to understand the mechanisms of action of the immunosuppressant drug rapamycin …

Angiogenesis in the pathophysiology of schizophrenia—a comprehensive review and a conceptual hypothesis

R Lopes, R Soares, R Coelho, M Figueiredo-Braga - Life sciences, 2015 - Elsevier
Schizophrenia (SZ) is a severe mental disorder poorly elucidated from the etiopathogenesis
prism. Recently, several micro-and macro-vascular abnormalities have been consistently …

Alterations in plasma vascular endothelial growth factor levels in patients with schizophrenia before and after treatment

BH Lee, JP Hong, JA Hwang, BJ Ham, KS Na… - Psychiatry …, 2015 - Elsevier
Vascular endothelial growth factor (VEGF), a potent angiogenetic factor, is a known
neurotrophic factor. In this study, we examined plasma levels of VEGF in 50 patients with …

mTOR signaling in the neuropathophysiology of depression: current evidence

GZ Réus, J Quevedo… - Journal of Receptor …, 2015 - Taylor & Francis
Despite significant progress in major depressive disorder (MDD) research over the past
decades, the mechanisms underlying its pathophysiology and treatment remain to be …

Chronic restraint stress increases the protein expression of VEGF and its receptor VEGFR‐2 in the prefrontal cortex

B Elfving, JL Jakobsen, JCB Madsen, G Wegener… - Synapse, 2015 - Wiley Online Library
The underlying molecular mechanisms of depression are complex and despite a
tremendous amount of research, not clearly understood. However, stress in particular, has …

血管内皮生长因子与抑郁症关系的临床研究进展

张庆玉, 王训强, 楼忠泽, 季蕴辛, 阮列敏 - 浙江医学, 2015 - cqvip.com
抑郁症是精神障碍中常见的一种疾病, 其终生患病率约10%. 自杀率高达15%:
神经营养假说认为, 脑内神经营养因子的不足会对神经系统的结构或功能造成影响 …

Mechanisms of action of 5α-tetrahydrocorticosterone, a novel anti-inflammatory glucocorticoid

A Gastaldello - 2015 - era.ed.ac.uk
Topical glucocorticoids (GCs), such as hydrocortisone (HC), are the main drugs used to treat
inflammatory skin conditions including eczema and psoriasis, but their longterm use is …

федеральное государственное бюджетное учреждение «Федеральный центр охраны здоровья животных»(ФГБУ «ВНИИЗЖ»)

ПБЗИ КОРМОВОГО, Н ЦЫПЛЯТ-БРОЙЛЕРОВ - old.stgau.ru
Реализация генетического потенциала животных и птиц невозможна без строго
соблюдения условий кормления и содержания, в частности необходимости …