Molecular mechanisms of acrolein toxicity: relevance to human disease
A Moghe, S Ghare, B Lamoreau… - Toxicological …, 2015 - academic.oup.com
Acrolein, a highly reactive unsaturated aldehyde, is a ubiquitous environmental pollutant
and its potential as a serious environmental health threat is beginning to be recognized …
and its potential as a serious environmental health threat is beginning to be recognized …
Reversibly crosslinked hyaluronic acid nanoparticles for active targeting and intelligent delivery of doxorubicin to drug resistant CD44+ human breast tumor xenografts
Y Zhong, J Zhang, R Cheng, C Deng, F Meng… - Journal of controlled …, 2015 - Elsevier
The existence of drug resistance poses a major obstacle for the treatment of various
malignant human cancers. Here, we report on reduction-sensitive reversibly crosslinked …
malignant human cancers. Here, we report on reduction-sensitive reversibly crosslinked …
The sodium/multivitamin transporter: a multipotent system with therapeutic implications
M Quick, L Shi - Vitamins & Hormones, 2015 - Elsevier
The Na+/multivitamin transporter (SMVT) is a member of the solute: sodium symporter family
that catalyzes the Na+-dependent uptake of the structurally diverse water-soluble vitamins …
that catalyzes the Na+-dependent uptake of the structurally diverse water-soluble vitamins …
Alpha-lipoic acid alone and combined with clozapine reverses schizophrenia-like symptoms induced by ketamine in mice: participation of antioxidant, nitrergic and …
GS Vasconcelos, NC Ximenes, CNS de Sousa… - Schizophrenia …, 2015 - Elsevier
Oxidative stress has important implications in schizophrenia. Alpha-lipoic acid (ALA) is a
natural antioxidant synthesized in human tissues with clinical uses. We studied the effect of …
natural antioxidant synthesized in human tissues with clinical uses. We studied the effect of …
Transcriptome analysis in calorie-restricted rats implicates epigenetic and post-translational mechanisms in neuroprotection and aging
Background Caloric restriction (CR) can increase longevity in rodents and improve memory
function in humans. α-Lipoic acid (LA) has been shown to improve memory function in rats …
function in humans. α-Lipoic acid (LA) has been shown to improve memory function in rats …
Protecting the BBB endothelium against cigarette smoke-induced oxidative stress using popular antioxidants: Are they really beneficial?
Abstract Blood Brain Barrier (BBB) exposed to realistic concentrations (comparable to a
chronic heavy smoker) of Cigarette Smoke Extract (CSE) triggers a strong endothelial …
chronic heavy smoker) of Cigarette Smoke Extract (CSE) triggers a strong endothelial …
Naringin ameliorates cognitive deficits via oxidative stress, proinflammatory factors and the PPARγ signaling pathway in a type 2 diabetic rat model
Z Qi, Y Xu, Z Liang, S Li, J Wang… - Molecular …, 2015 - spandidos-publications.com
Naringenin is a flavonoid polyphenolic compound, which facilitates the removal of free
radicals, oxidative stress and inflammation. The present study aimed to obtain a better …
radicals, oxidative stress and inflammation. The present study aimed to obtain a better …
[HTML][HTML] Effect of Rheum ribes hydro-alcoholic extract on memory impairments in rat model of Alzheimer's disease
M Zahedi, MR Hojjati, H Fathpour, Z Rabiei… - Iranian Journal of …, 2015 - ncbi.nlm.nih.gov
Some animal models have been used to study Alzheimer's disease (AD). AD is an
irreversible progressive neurodegenerative disease and the most common cause of …
irreversible progressive neurodegenerative disease and the most common cause of …
The metabolism hypothesis of Alzheimer's disease: from the concept of central insulin resistance and associated consequences to insulin therapy
K Morgen, L Frölich - Journal of Neural Transmission, 2015 - Springer
The concept of central insulin resistance and dysfunctional insulin signaling in Alzheimer's
disease (AD) has been developed by Siegfried Hoyer in 1985–2000. It is widely recognized …
disease (AD) has been developed by Siegfried Hoyer in 1985–2000. It is widely recognized …
Therapeutic approaches to modulating glutathione levels as a pharmacological strategy in Alzheimer's disease
N Braidy, M Zarka, J Welch… - Current Alzheimer …, 2015 - ingentaconnect.com
Accumulating evidence has suggested the involvement of oxidative stress in the
pathogenesis of Alzheimer's disease (AD). The main endogenous antioxidant, glutathione …
pathogenesis of Alzheimer's disease (AD). The main endogenous antioxidant, glutathione …