The blood–brain barrier
R Daneman, A Prat - Cold Spring Harbor perspectives in …, 2015 - cshperspectives.cshlp.org
Blood vessels are critical to deliver oxygen and nutrients to all of the tissues and organs
throughout the body. The blood vessels that vascularize the central nervous system (CNS) …
throughout the body. The blood vessels that vascularize the central nervous system (CNS) …
T cell subsets and their signature cytokines in autoimmune and inflammatory diseases
Abstract CD4+ T helper (Th) cells are critical for proper immune cell homeostasis and host
defense, but are also major contributors to pathology of autoimmune and inflammatory …
defense, but are also major contributors to pathology of autoimmune and inflammatory …
Neutrophils promote Alzheimer's disease–like pathology and cognitive decline via LFA-1 integrin
E Zenaro, E Pietronigro, VD Bianca, G Piacentino… - Nature medicine, 2015 - nature.com
Inflammation is a pathological hallmark of Alzheimer's disease, and innate immune cells
have been shown to contribute to disease pathogenesis. In two transgenic models of …
have been shown to contribute to disease pathogenesis. In two transgenic models of …
Th17 cell pathway in human immunity: lessons from genetics and therapeutic interventions
DD Patel, VK Kuchroo - Immunity, 2015 - cell.com
The T helper 17 (Th17) cell pathway has been linked by genome-wide association studies to
multiple autoimmune diseases. Identification of the genetic causes of primary …
multiple autoimmune diseases. Identification of the genetic causes of primary …
Animal models of multiple sclerosis
Multiple Sclerosis (MS) is an inflammatory demyelinating disease of the central nervous
system (CNS) which involves a complex interaction between immune system and neural …
system (CNS) which involves a complex interaction between immune system and neural …
The development and in vivo function of T helper 9 cells
The specialized cytokine secretion profiles of T helper (TH) cells are the basis for a focused
and efficient immune response. On the twentieth anniversary of the first descriptions of the …
and efficient immune response. On the twentieth anniversary of the first descriptions of the …
The role of IL-17 in CNS diseases
Cytokines of the IL-17 family are uniquely placed on the border between immune cells and
tissue. Although IL-17 was originally found to induce the activation and mobilization of …
tissue. Although IL-17 was originally found to induce the activation and mobilization of …
Transmembrane proteins of the tight junctions at the blood–brain barrier: structural and functional aspects
RF Haseloff, S Dithmer, L Winkler, H Wolburg… - Seminars in cell & …, 2015 - Elsevier
The blood–brain barrier (BBB) is formed by microvascular endothelial cells sealed by
tetraspanning tight junction (TJ) proteins, such as claudins and TAMPs (TJ-associated …
tetraspanning tight junction (TJ) proteins, such as claudins and TAMPs (TJ-associated …
Leukocyte integrins: role in leukocyte recruitment and as therapeutic targets in inflammatory disease
Infection or sterile inflammation triggers site-specific attraction of leukocytes. Leukocyte
recruitment is a process comprising several steps orchestrated by adhesion molecules …
recruitment is a process comprising several steps orchestrated by adhesion molecules …
Sodium intake is associated with increased disease activity in multiple sclerosis
Background Recently, salt has been shown to modulate the differentiation of human and
mouse Th17 cells and mice that were fed a high-sodium diet were described to develop …
mouse Th17 cells and mice that were fed a high-sodium diet were described to develop …